Evidence map›Paper›PMID 37749394›Full record

ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2023

Central sensitization negatively influences the level of disability in female patients with anterior knee pain.

Vicente Sanchis-Alfonso, María Beser-Robles, Ana Navarro-Calvo, Laura López-Company, Alejandro Roselló-Añón, Julio Domenech-Fernández

Abstract read
PubMed Publisher
In one paragraph

Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. [Idiopathic anterior knee pain-what is the problem?]Orthopadie (Heidelberg, Germany) · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Vicente Sanchis-AlfonsoDepartment of Orthopedic Surgery, Hospital Arnau de Vilanova, C/San Clemente 12, 46015, Valencia, Spain. vicente.sanchis.alfonso@gmail.com.
María Beser-RoblesGIBI230 Research Group on Biomedical Imaging, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.
Ana Navarro-CalvoDepartment of Rehabilitation and Physical Therapy, Hospital Arnau de Vilanova, Valencia, Spain.
Laura López-CompanyDepartment of Rehabilitation and Physical Therapy, Hospital Arnau de Vilanova, Valencia, Spain.
Alejandro Roselló-AñónDepartment of Orthopedic Surgery, Hospital Arnau de Vilanova, C/San Clemente 12, 46015, Valencia, Spain.
Julio Domenech-FernándezDepartment of Orthopedic Surgery, Clínica Universidad de Navarra, Pamplona, Spain.
Hospital Arnau de Vilanova · ESInstituto de Investigación Sanitaria La Fe · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo define the prevalence of Central Sensitization (CS) in patients with Anterior Knee Pain (AKP) and determine whether there is an association between CS and the magnitude of pain, disability, quality-of-life and psychological impairment.

methodsThe data of a total of 44 AKP female patients with a mean age of 27.7 years (15-50) recruited consecutively from hospital outpatient knee clinics were prospectively included in this study. The patients had no antecedents of knee trauma or surgery and no history of injury or disease of the nervous system. There were also 50 healthy female controls with a mean age of 26.1 years (16-46). CS was evaluated using the Central Sensitization Inventory (CSI). Quality-of-life was evaluated using the EuroQoL-5D questionnaire. Self-reporting of clinical pain intensity was obtained using the Visual Analogue Scale. The Kujala Knee Scale and IKDC form were used to evaluate disability. Anxiety and depression were evaluated using the Hospital Anxiety and Depression Subscale (HAD). Kinesiophobia was measured with the Tampa Scale for Kinesiophobia (TSK-11) and catastrophizing by means of the Pain Catastrophizing Scale (PCS).

resultsSixteen AKP patients (36%), and 2 (4%) of the healthy controls presented with central sensitization (p < 0.01). AKP patients with CS have a greater degree of disability based on the Kujala Scale and higher levels of anxiety and depression than AKP patients without CS. The score of AKP patients in the CSI correlated weakly with disability and quality of life and moderately with anxiety and depression. However, no association was seen between CSI score and pain intensity, nor with catastrophizing and kinesiophobia. A multivariate logistic regression analysis showed that only depression was statistically significant in the prediction of the presence of CS (odds ratio 1.45; 95% CI 1.07 to 1.96).

conclusionsAKP patients have a significantly higher prevalence of CS in comparison with what has been reported for the general population. This finding suggests the presence of altered pain modulation in a subgroup of AKP patients. LEVEL OF EVIDENCE: Level III.

Indexed as

Central Nervous System SensitizationQuality of LifeAdultFemaleHumansKneeKnee JointPainAnterior knee painCentral sensitizationCentral sensitization inventoryChronic painPatellofemoral pain

Identifiers

PMID37749394
OpenAlexW4387012363

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.