ArticleJournal of the American Heart Association2023
Sustained Increases in Cardiomyocyte Protein
Open access · goldAbstract read
In one paragraph
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 19 citations in OpenAlex.
- Transient elevation in cellular glucose uptake exacerbates pressure overload-induced cardiac hypertrophy and dysfunction.Epigenetics · 2026Article
- Impact of renal iron overload on sickle cell nephropathy in a humanized mouse model.American journal of physiology. Renal physiology · 2026Article
- Metabolic phenotypes of doxorubicin-induced cardiotoxicity among patients with breast cancer.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- O-GlcNAcylation as a Metabolic Integrator in Cardiovascular Physiology and Disease.International journal of molecular sciences · 2026Review
- Glycosylation Profiles in Cardiovascular Diseases: A Bibliometric Analysis.Health data science · 2026Article
- Is Type 2 Diabetes a Modifiable Risk Factor for the Evolution and Progression of Heart Failure With a Preserved Ejection Fraction?Journal of the American College of Cardiology · 2025Review
- Adropin protects against cardiac remodeling and metabolic dysfunction in a mouse model of HFpEF.bioRxiv : the preprint server for biology · 2025Article
- PFKFB2 Is Pivotal for Metabolic Flexibility and Differential Glucose Utilization.Journal of the American Heart Association · 2025Article
- Sex alters thyroid hormone's effect on protein O-GlcNAcylation in the aged mouse heart.BMC molecular and cell biology · 2025Article
- Deficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction.Cardiovascular diabetology · 2025Article
- Severe attenuation of circadian clock output in the heart following sustained augmentation of cardiomyocyte protein O-GlcNAcylation.Frontiers in cardiovascular medicine · 2025Article
- Decoding glycosylation in cardiovascular diseases: mechanisms, biomarkers, and therapeutic opportunities.Frontiers in pharmacology · 2025Review
- Review
- The role of protein O-GlcNAcylation in diabetic cardiomyopathy.Biochemical Society transactions · 2024Review
- Protein glycosylation in cardiovascular health and disease.Nature reviews. Cardiology · 2024Review
- Roles of O-GlcNAcylation in Mitochondrial Homeostasis and Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- ROCK Inhibitor Fasudil Attenuates Neuroinflammation and Associated Metabolic Dysregulation in the Tau Transgenic Mouse Model of Alzheimer's Disease.Current Alzheimer research · 2024Article
- O-GlcNAcylation in ischemic diseases.Frontiers in pharmacology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 1 institution in 1 country.
Chae-Myeong HaDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0003-2617-2698
Sayan BakshiDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-6717-6049
Manoja K BrahmaDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0003-3191-0720
Luke A PotterDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-1736-2898
Samuel F ChangDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0001-5083-3957
Zhihuan SunDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0003-0945-0182
Gloria A BenavidesDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-2640-974X
Lihao HeDivision of Cardiovascular Disease, Department of Medicine University of Alabama at Birmingham Birmingham AL.ORCID 0000-0001-8361-032X
Prachi UmbarkarDivision of Cardiovascular Disease, Department of Medicine University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-7989-577X
Luyun ZouDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.
Samuel CurfmanDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-3350-7911
Sini SunnyDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-9115-9943
Andrew J PatersonDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-6247-1911
Namakkal-Soorappan RajasekaranDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0001-7152-1573
Jarrod W BarnesDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-1027-6591
Jianhua ZhangDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-2128-9574
Hind LalDivision of Cardiovascular Disease, Department of Medicine University of Alabama at Birmingham Birmingham AL.ORCID 0000-0001-8980-9874
Min XieDivision of Cardiovascular Disease, Department of Medicine University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-2967-3490
Victor M Darley-UsmarDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0001-8921-7086
John C ChathamDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0001-7180-9948
Adam R WendeDivision of Molecular and Cellular Pathology, Department of Pathology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-5536-4675
University of Alabama at Birmingham · US
Funding
Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9MUniversity of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2013 to 2026
$19.5MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8MSex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Daniel L Smith · 2015 to 2026
$11.3MInterdisciplinary Training in Pathobiology and Rehabilitation Medicine.T32HD071866 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAMES RIMMER, Anna E. Thalacker-Mercer · 2012 to 2026
$4.8MReductive Stress Induces Proteotoxic Cardiac DiseaseR01HL118067 · NHLBI · UNIVERSITY OF UTAH · PI NAMAKKAL SOORAPPAN, RAJASEKARAN · 2013 to 2021
$4.5MSignaling Mechanisms Governing Myocardial Fibrosis in Diseased HeartR01HL133290 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Hind Lal · 2017 to 2026
$3.6MProject-002R01HL143074 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Hind Lal · 2019 to 2026
$3.4MMetabolic Landscape of the Aging LungR01HL152246 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARNES, JARROD W., THANNICKAL, VICTOR J. · 2020 to 2023
$3.2MNovel strategies to mitigate cardiac damage and dysfunction following invasive pneumococcal diseaseR01HL171136 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Hind Lal, Carlos J Orihuela · 2024 to 2026
$1.8MGlucose-Mediated Remodeling of Cardiac DNA MethylationR01HL133011 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WENDE, ADAM RAYMOND · 2017 to 2020
$1.5MNovaSeq 6000 Sequencing SystemS10OD032422 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CROWLEY, MICHAEL R · 2022 to 2022
$945kBLRD VA I01 BX003056NHLBI NIH HHS F31 HL154571NHLBI NIH HHS R01 HL118067NHLBI NIH HHS R01 HL133011NHLBI NIH HHS R01 HL133290NHLBI NIH HHS R01 HL143074NHLBI NIH HHS R01 HL152246NHLBI NIH HHS R01 HL171136NHLBI NIH HHS R21 HL152354NIA NIH HHS P30 AG050886NIA NIH HHS R03 AG042860NIA NIH HHS R56 AG060959NICHD NIH HHS T32 HD071866NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30 DK079626NIGMS NIH HHS T32 GM008361NIH HHS S10 OD032422
Abstract
Background Lifestyle and metabolic diseases influence the severity and pathogenesis of cardiovascular disease through numerous mechanisms, including regulation via posttranslational modifications. A specific posttranslational modification, the addition of
Indexed as
Cardiovascular DiseasesMyocytes, CardiacAcetylglucosamineAnimalsCardiomegalyDisease Models, AnimalGlycosylationMiceMitochondriaN-AcetylglucosaminyltransferasesProtein Processing, Post-TranslationalAcetylglucosamineN-Acetylglucosaminyltransferasescardiac remodelingdiabetic cardiomyopathymetabolismmitochondriaprotein O‐GlcNAcylation
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.