Evidence map›Paper›PMID 37750733›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2023

Negative and ambisense RNA virus ribonucleocapsids: more than protective armor.

Kimberly R Sabsay, Aartjan J W Te Velthuis

Open access · greenAbstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Structural Features of Nucleoproteins from the Recently DiscoveredInternational journal of molecular sciences · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kimberly R SabsayLewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.ORCID 0000-0003-2204-2693
Aartjan J W Te VelthuisLewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.ORCID 0000-0002-5129-3953
Princeton University · US

Funding

Functional and genetic constraints on influenza virus replication and fidelityR01AI170520 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAURING, ADAM · 2022 to 2025
$2.4M
Structure and dynamics of RNA elements regulating viral aberrant RNA synthesisDP2AI175474 · NIAID · PRINCETON UNIVERSITY · PI TE VELTHUIS, AREND JAN · 2022 to 2025
$2.4M
Learning principles from the pyrenoid, a phase-separated organelleR01GM140032 · NIGMS · PRINCETON UNIVERSITY · PI JONIKAS, MARTIN CASIMIR, WINGREEN, NED S · 2021 to 2024
$2.0M
NIAID NIH HHS DP2 AI175474NIAID NIH HHS R01 AI170520NIGMS NIH HHS R01 GM140032Wellcome Trust
6 · The paper itself

Abstract

Negative and ambisense RNA viruses are the causative agents of important human diseases such as influenza, measles, Lassa fever, and Ebola hemorrhagic fever. The viral genome of these RNA viruses consists of one or more single-stranded RNA molecules that are encapsidated by viral nucleocapsid proteins to form a ribonucleoprotein complex (RNP). This RNP acts as protection, as a scaffold for RNA folding, and as the context for viral replication and transcription by a viral RNA polymerase. However, the roles of the viral nucleoproteins extend beyond these functions during the viral infection cycle. Recent advances in structural biology techniques and analysis methods have provided new insights into the formation, function, dynamics, and evolution of negative sense virus nucleocapsid proteins, as well as the role that they play in host innate immune responses against viral infection. In this review, we discuss the various roles of nucleocapsid proteins, both in the context of RNPs and in RNA-free states, as well as the open questions that remain.

Indexed as

RNA VirusesVirus DiseasesHumansNucleocapsid ProteinsRibonucleoproteinsRNA, ViralVirus ReplicationNucleocapsid ProteinsRibonucleoproteinsRNA, Viralambisense virusinfluenza A virusinnate immunenegative sense RNA virusNPnucleoproteinRdRpRNA polymeraseRNA structureRNPt-loop

Identifiers

PMID37750733
PMCPMC10732063
OpenAlexW4387033359

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.