Evidence map›Paper›PMID 37755265›Full record

ArticleMetabolites2023

Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites.

Dhwani Patel, Iain A Murray, Fangcong Dong, Andrew J Annalora, Krishne Gowda, Denise M Coslo, Jacek Krzeminski, Imhoi Koo, Fuhua Hao, Shantu G Amin and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Dhwani PatelDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-9368-2850
Iain A MurrayDepartment of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.
Fangcong DongDepartment of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-6423-5816
Andrew J AnnaloraDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.
Krishne GowdaDepartment of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA.
Denise M CosloDepartment of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.
Jacek KrzeminskiDepartment of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA.
Imhoi KooDepartment of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-5816-0627
Fuhua HaoDepartment of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-0865-5269
Shantu G AminDepartment of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA.
Craig B MarcusDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0001-7759-2532
Andrew D PattersonDepartment of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0003-2073-0070
Gary H PerdewDepartment of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA.
Pennsylvania State University · USOregon State University · US

Funding

Activation of the Ah receptor and epithelial integrityR35ES028244 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PERDEW, GARY H. · 2017 to 2024
$6.2M
Environmental Chemical Impact on the Host-Microbiome InteractionR35ES035027 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Andrew Patterson · 2023 to 2026
$3.6M
Environmental Ah Receptor Ligand Impact on the Host-Microbiome Metabolic AxisR01ES028288 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW · 2017 to 2021
$1.7M
Acquisition of an Orbitrap Fusion Lumos Tribid Mass Spectrometer to Accelerate Metabolite Identification and Pathway AnalysisS10OD021750 · OD · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW · 2017 to 2017
$966k
Integrative Analysis of Metabolic Phenotypes (IAMP) Predoctoral Training ProgramT32DK120509 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW, PERDEW, GARY H. · 2020 to 2024
$781k
NIDDK NIH HHS T32 DK120509NIDDK NIH HHS T32DK120509NIEHS NIH HHS ES028244NIEHS NIH HHS ES028288NIEHS NIH HHS ES035027NIEHS NIH HHS R01 ES028288NIEHS NIH HHS R35 ES028244NIEHS NIH HHS R35 ES035027NIH HHS S10 OD021750
6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that plays an important role in gastrointestinal barrier function, tumorigenesis, and is an emerging drug target. The resident microbiota is capable of metabolizing tryptophan to metabolites that are AHR ligands (e.g., indole-3-acetate). Recently, a novel set of mutagenic tryptophan metabolites named indolimines have been identified that are produced by

Indexed as

AHRAh receptorcancerCYP1A1indoliminetryptophan

Identifiers

PMID37755265
PMCPMC10535990
OpenAlexW4386324477

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.