Evidence map›Paper›PMID 37756164›Full record

ArticleCell reports2023

Reciprocal transmission of activating and inhibitory signals and cell fate in regenerating T cells.

Peter H Wang, Robert S Washburn, Dylan L Mariuzza, Wen-Hsuan W Lin, Amanda L Gill, Rafi Ahmed, Steven L Reiner

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Regulators of CD8Nature reviews. Immunology · 2026
    Review
  4. Article
  5. Review
  6. A guide to adaptive immune memory.Nature reviews. Immunology · 2024
    Review
  7. Review
  8. Immune checkpoints in autoimmune vasculitis.Best practice & research. Clinical rheumatology · 2024
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Peter H WangDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Robert S WashburnDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Dylan L MariuzzaDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Wen-Hsuan W LinDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Amanda L GillEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.
Rafi AhmedEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.
Steven L ReinerDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: sr2978@cumc.columbia.edu.
Columbia University · USEmory University · USColumbia University Irving Medical Center · US

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Medical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3M
Medical Scientist Training ProgramT32GM142617 · NIGMS · EMORY UNIVERSITY · PI Jason Yustein · 2022 to 2026
$7.0M
T CELL MEMORY TO VIRUSESR01AI030048 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AHMED, RAFI · 1990 to 2022
$5.2M
Strategies to predict and overcome resistance to cancer immunotherapyR01CA279268 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2023 to 2026
$2.2M
Columbia University Graduate Training Program in Microbiology and ImmunologyT32AI106711 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Nicholas Arpaia, Uttiya Basu · 2014 to 2026
$2.1M
Self-renewing Lymphocyte Division in The Immune ResponseR56AI076458 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REINER, STEVEN L · 2014 to 2021
$802k
Millipore Sigma ImageStream-X Mark II Imaging CytometerS10OD026845 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PASSEGUE, EMMANUELLE · 2019 to 2019
$553k
NCI NIH HHS P30 CA013696NCI NIH HHS R01 CA279268NIAID NIH HHS R01 AI030048NIAID NIH HHS R56 AI076458NIAID NIH HHS T32 AI106711NIGMS NIH HHS T32 GM142617NIGMS NIH HHS T32 GM145440NIH HHS S10 OD026845
6 · The paper itself

Abstract

The ability of activated progenitor T cells to self-renew while producing differentiated effector cell descendants may underlie immunological memory and persistent responses to ongoing infection. The nature of stem-like T cells responding to cancer and during treatment with immunotherapy is not clear. The subcellular organization of dividing progenitor CD8

Indexed as

CD8-Positive T-LymphocytesPhosphatidylinositol 3-KinasesAnimalsCell DifferentiationMiceSignal TransductionStem CellsPhosphatidylinositol 3-Kinasesasymmetric cell divisioncancer immunotherapyCD8(+) T cellCP: Cell biologyPD-1PI3Kself-renewalstem cellTCF1

Identifiers

PMID37756164
PMCPMC10872930
OpenAlexW4387072784

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.