Evidence map›Paper›PMID 37758276›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2023

Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis.

Jilly F Evans, Francis X McCormack, Nahum Sonenberg, Vera P Krymskaya

Open access · diamondAbstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Current insight into the molecular mechanisms of lymphangioleiomyomatosis.American journal of respiratory cell and molecular biology · 2026
    Review
  2. The Bi-steric Inhibitor RMC-5552 Reduces mTORC1 Signaling and Growth in Lymphangioleiomyomatosis.American journal of respiratory cell and molecular biology · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Pleural Fibrosis: Now That's What mTORC(ing) About.American journal of respiratory cell and molecular biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Jilly F EvansDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA jillyfevans@gmail.com.
Francis X McCormackDivision of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, Cincinnati, OH, USA.
Nahum SonenbergDepartment of Biochemistry and Goodman Cancer Institute, McGill University, Montreal, QC, Canada.
Vera P KrymskayaDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USMcGill University · CAUniversity of Cincinnati · US

Funding

The Molecular and Genetic Pathogensis of LAMU01HL131022 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HENSKE, ELIZABETH P · 2016 to 2024
$5.7M
Multicenter Interventional Lymphangioleiomyomatosis Early Disease Trial (MILED)-CCCU01HL131755 · NHLBI · UNIVERSITY OF CINCINNATI · PI MCCORMACK, FRANCIS XAVIER · 2016 to 2021
$3.6M
mTORC1 and WNT in lung mesenchymeR01HL158737 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KRYMSKAYA, VERA P · 2021 to 2024
$2.5M
mTOR signaling in lung homeostasis, aging and diseaseR01HL151467 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KRYMSKAYA, VERA P · 2020 to 2023
$2.0M
Urokinase-type plasminogen activator (uPA) in pathogenesis of lymphangioleiomyomatosis (LAM)R01HL141462 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KRYMSKAYA, VERA P, STEPANOVA, VICTORIA · 2019 to 2022
$1.8M
NHLBI NIH HHS R01 HL141462NHLBI NIH HHS R01 HL151467NHLBI NIH HHS R01 HL158737NHLBI NIH HHS U01 HL131022NHLBI NIH HHS U01 HL131755
6 · The paper itself

Abstract

Lymphangioleiomyomatosis (LAM) is a cystic lung disease of women resulting from mutations in tuberous sclerosis complex (TSC) genes that suppress the mammalian target of rapamycin complex 1 (mTORC1) pathway. mTORC1 activation enhances a plethora of anabolic cellular functions, mainly

Indexed as

LymphangioleiomyomatosisEukaryotic Initiation Factor-4EFemaleHumansMechanistic Target of Rapamycin Complex 1SirolimusTOR Serine-Threonine KinasesEukaryotic Initiation Factor-4EMechanistic Target of Rapamycin Complex 1SirolimusTOR Serine-Threonine Kinases

Identifiers

PMID37758276
PMCPMC10523142
OpenAlexW4387100945

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.