Evidence map›Paper›PMID 37759042›Full record

ReviewClinical and experimental medicine2023

Advances in the pathogenesis and therapeutic strategies of angioimmunoblastic T-cell lymphoma.

Qingyang Zhang, Le Yin, Qinqiao Lai, Yan Zhao, Hongling Peng

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical and experimental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qingyang ZhangDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Le YinDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Qinqiao LaiDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Yan ZhaoDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Hongling PengDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. penghongling@csu.edu.cn.
Central South University · CN

Funding

National Natural Science Foundation of China 82070175Natural Science Foundation of Hunan Province 2022JJ30830the Scientific program of the Health Commission of Hunan Province 20201179
6 · The paper itself

Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell lymphomas with its cell origin determined to be follicular helper T-cells. AITL is characterized by a prominent tumor microenvironment involving dysregulation of immune cells, signaling pathways, and extracellular matrix. Significant progress has been made in the molecular pathophysiology of AITL, including genetic mutations, immune metabolism, hematopoietic-derived microenvironment, and non-hematopoietic microenvironment cells. Early diagnosis, detection of severe complications, and timely effective treatment are crucial for managing AITL. Treatment typically involves various combination chemotherapies, but the prognosis is often poor, and relapsed and refractory AITL remains challenging, necessitating improved treatment strategies. Therefore, this article provides an overview of the pathogenesis and latest advances in the treatment of AITL, with a focus on potential therapeutic targets, novel treatment strategies, and emerging immunotherapeutic approaches.

Indexed as

Immunoblastic LymphadenopathyLymphoma, T-Cell, PeripheralHumansMutationSignal TransductionTumor MicroenvironmentAngioimmunoblastic T-cell lymphomaPathogenesisTherapeutic strategies

Identifiers

PMID37759042
OpenAlexW4387091770

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.