Evidence map›Paper›PMID 37759141›Full record

ArticleCell and tissue research2023

Exploration of eMSCs with HA-GEL system in repairing damaged endometrium after endometrial cancer with fertility-sparing treatment.

Wei Liu, Mengxin Hao, Yuhui Xu, Xiaojun Ren, Jiali Hu, Lulu Wang, Xiaojun Chen, Qiaoying Lv

Abstract read
PubMed Publisher
In one paragraph

Article in Cell and tissue research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Wei LiuObstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Shanghai, China.
Mengxin HaoObstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Shanghai, China.
Yuhui XuObstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Shanghai, China.
Xiaojun RenObstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Shanghai, China.
Jiali HuObstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Shanghai, China.
Lulu WangObstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Shanghai, China.
Xiaojun ChenObstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Shanghai, China. xiaojunchen2013@sina.com.ORCID http://orcid.org/0000-0002-5493-1500
Qiaoying LvObstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Shanghai, China. lvqiaoying@126.com.
Obstetrics and Gynecology Hospital of Fudan University · CN

Funding

National Key Technology R&D Program of China No. 2019YFC1005200National Key Technology R&D Program of China No. 2019YFC1005203
6 · The paper itself

Abstract

Despite the high complete response rate of fertility-sparing treatment in early-stage endometrial cancer (EC), the low pregnancy rate is a clinical challenge. Whether endometrium-derived mesenchymal stem cells (eMSCs) can repair damaged endometrium after EC reversal remains unclear. This study explored the potential therapeutic effects of eMSCs with suitable scaffold materials on endometrial damage caused by EC. Here, appropriate engineering scaffold materials were compared to identify the most suitable materials to carry eMSCs. Then, safety and efficacy evaluations of eMSCs with a suitable hyaluronic acid hydrogel (eMSCs/HA-GEL) were investigated in in vivo experiments with subcutaneous xenotransplantation in Balb/C nude mice and a model of endometrial mechanical injury in rats. HA-GEL has minimal cytotoxicity to eMSCs compared to other materials. Then, in vitro experiments demonstrate that eMSCs/HA-GEL enhance the inhibitory effects of progestins on EC cell biological behaviors. eMSCs/HA-GEL significantly inhibit EC cell growth and have no potential safety hazards of spontaneous tumorigenesis in Balb/C nude mouse subcutaneous xenotransplantation assays. eMSCs/HA-GEL intrauterine transplantation effectively increases endometrial thickness and glandular number, improves endometrial blood supply, reduces fibrotic areas, and improves pregnancy rates in a rat endometrial mechanical injury model. GFP-eMSCs/HA-GEL intrauterine transplantation in rats shows more GFP-eMSCs in the endometrium than GFP-eMSCs transplantation alone, and no tumor formation or suspicious cell nodules are found in the liver, kidney, or lung tissues. Our results reveal the safety and efficacy of eMSCs/HA-GEL in animal models and provide preliminary evidence for the use of eMSCs/HA-GEL as a treatment for EC-related endometrial damage.

Indexed as

Endometrial NeoplasmsMesenchymal Stem CellsAnimalsEndometriumFemaleHumansMiceMice, NudeRatsTransplantation, HeterologousEndometrial cancerEndometrial regenerationEndometrum-derived mesenchymal stem cellsFertility-sparing treatmentHyaluronic acid hydrogel

Identifiers

PMID37759141
OpenAlexW4387115304

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.