A Greater Increase in Complement C5a Receptor 1 Level at Onset and a Smaller Decrease in Immunoglobulin G Level after Recovery in Severer Coronavirus Disease 2019 Patients: A New Analysis of Existing Data with a New Two-Tailed

Torao Ishida, Ken Takagi, Guifeng Wang, Nobuyuki Tanahashi, Jun Kawanokuchi, Hisayo Takagi, Yi Guo, Ning Ma

Abstract readReview

In one paragraph

Review in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Torao IshidaProject for Advanced Science, Suzuka University of Medical Science, Suzuka 510-0293, Japan.

Ken TakagiProject for Advanced Science, Suzuka University of Medical Science, Suzuka 510-0293, Japan.

Guifeng WangProject for Advanced Science, Suzuka University of Medical Science, Suzuka 510-0293, Japan.ORCID 0000-0003-0716-0974

Nobuyuki TanahashiProject for Advanced Science, Suzuka University of Medical Science, Suzuka 510-0293, Japan.

Jun KawanokuchiProject for Advanced Science, Suzuka University of Medical Science, Suzuka 510-0293, Japan.

Hisayo TakagiProject for Advanced Science, Suzuka University of Medical Science, Suzuka 510-0293, Japan.

Yi GuoCollege of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Ning MaProject for Advanced Science, Suzuka University of Medical Science, Suzuka 510-0293, Japan.ORCID 0000-0001-7315-8835

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: It is our purpose to identify the differences in the changes in Complement C5a receptor 1 (C5aR1) levels showing the degree of inflammation at onset and Immunoglobulin G (IgG) levels showing the extent of survival of the virus fragments after recovery between coronavirus disease 2019 (COVID-19) and pneumonia coronavirus disease (non-COVID-19) for saving patients' lives. (2) Methods: First, the studies showing these markers' levels in individual patients before and after the passage of time were selected from the PubMed Central

Indexed as

a greater increase in C5aR1 level at onseta new analysis with Ishida’s t-test1 and t-test2a smaller decrease in IgG level after recoveryseverer COVID-19 patients

Identifiers

PMID37759576

DOI10.3390/biology12091176

PMCPMC10525237

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.