Evidence map›Paper›PMID 37759587›Full record

ReviewBiology2023

Biodiversity of Skin Microbiota as an Important Biomarker for Wound Healing.

Caglar Ersanli, Athina Tzora, Chrysoula Chrysa Voidarou, Stylianos Skoufos, Dimitrios I Zeugolis, Ioannis Skoufos

Registry-linked trialAbstract readReview
In one paragraph

Review in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07209007 (An Exploratory Study on the Dynamics of Microbiome Dysbiosis), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07209007 recruitingnot on this mapstarted 2025, after this paper: background citation

An Exploratory Study on the Dynamics of Microbiome Dysbiosis (Microbial Imbalance) in the Skin and Gut Microbiome of Burn Patients

TypeobservationalSponsorCho Yoon sooRan2025 to 2030Enrolled600ConditionsBurn Injuries, Skin Disease, Microbiome, Microbiome DysbiosisArmsNo Intervention: Observational Cohort
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Release Profile and Antibacterial Activity ofBioengineering (Basel, Switzerland) · 2025
    Article
  9. Article
  10. Skin Microbiome in Health and Disease: Mechanisms and Emerging Therapeutic Strategies.Clinical, cosmetic and investigational dermatology · 2025
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caglar ErsanliLaboratory of Animal Science, Nutrition and Biotechnology, Department of Agriculture, University of Ioannina, 47100 Arta, Greece.ORCID 0000-0003-1256-4113
Athina TzoraLaboratory of Animal Health, Food Hygiene and Quality, Department of Agriculture, University of Ioannina, 47100 Arta, Greece.ORCID 0000-0003-2615-7068
Chrysoula Chrysa VoidarouLaboratory of Animal Health, Food Hygiene and Quality, Department of Agriculture, University of Ioannina, 47100 Arta, Greece.ORCID 0000-0002-8035-1710
Stylianos SkoufosLaboratory of Animal Health, Food Hygiene and Quality, Department of Agriculture, University of Ioannina, 47100 Arta, Greece.
Dimitrios I ZeugolisRegenerative, Modular & Developmental Engineering Laboratory (REMODEL), Charles Institute of Dermatology, Conway Institute of Biomolecular and Biomedical Research, School of Mechanical and Materials Engineering, University College Dublin, D04 V1W8 Dublin, Ireland.ORCID 0000-0002-7599-5191
Ioannis SkoufosLaboratory of Animal Science, Nutrition and Biotechnology, Department of Agriculture, University of Ioannina, 47100 Arta, Greece.

Funding

European Union, EuroNanoMed3, project nAngioDerm, through the Greek General Secretariat for Research and Innovation ERA-NETS (code number T9EPA3-00022) T9EPA3-00022
6 · The paper itself

Abstract

Cutaneous wound healing is a natural and complex repair process that is implicated within four stages. However, microorganisms (e.g., bacteria) can easily penetrate through the skin tissue from the wound bed, which may lead to disbalance in the skin microbiota. Although commensal and pathogenic bacteria are in equilibrium in normal skin, their imbalance in the wound area can cause the delay or impairment of cutaneous wounds. Moreover, skin microbiota is in constant crosstalk with the immune system and epithelial cells, which has significance for the healing of a wound. Therefore, understanding the major bacteria species in the cutaneous wound as well as their communication with the immune system has gained prominence in a way that allows for the emergence of a new perspective for wound healing. In this review, the major bacteria isolated from skin wounds, the role of the crosstalk between the cutaneous microbiome and immune system to heal wounds, the identification techniques of these bacteria populations, and the applied therapies to manipulate the skin microbiota are investigated.

Indexed as

coagulase-negative S. aureusLactobacillimanipulation strategiesP. aeruginosaS. aureusskin microbiotawound healing

Identifiers

PMID37759587
PMCPMC10525143

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.