Evidence map›Paper›PMID 37759826›Full record

ArticleBiomolecules2023

Coupled Electrostatic and Hydrophobic Destabilisation of the Gelsolin-Actin Complex Enables Facile Detection of Ovarian Cancer Biomarker Lysophosphatidic Acid.

Katharina Davoudian, Shayon Bhattacharya, Damien Thompson, Michael Thompson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Katharina DavoudianDepartment of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada.ORCID 0000-0002-9675-4899
Shayon BhattacharyaSSPC-The Science Foundation Ireland Research Centre for Pharmaceuticals, V94 T9PX Limerick, Ireland.ORCID 0000-0002-4218-0308
Damien ThompsonSSPC-The Science Foundation Ireland Research Centre for Pharmaceuticals, V94 T9PX Limerick, Ireland.
Michael ThompsonDepartment of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada.ORCID 0000-0002-1445-9918
Science Foundation Ireland · IEUniversity of Toronto · CA

Funding

CIHR PJT 180421
6 · The paper itself

Abstract

Lysophosphatidic acid (LPA) is a promising biomarker candidate to screen for ovarian cancer (OC) and potentially stratify and treat patients according to disease stage. LPA is known to target the actin-binding protein gelsolin which is a key regulator of actin filament assembly. Previous studies have shown that the phosphate headgroup of LPA alone is inadequate to bind to the short chain of amino acids in gelsolin known as the PIP

Indexed as

Biomarkers, TumorOvarian NeoplasmsActinsFemaleGelsolinHumansHydrophobic and Hydrophilic InteractionsLysophospholipidsStatic ElectricityActinsBiomarkers, TumorGelsolinLysophospholipidsactingelsolinlipid-protein interactionlysophosphatidic acidovarian cancerpredictive molecular modelling

Identifiers

PMID37759826
PMCPMC10527313
OpenAlexW4386911580

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.