Evidence map›Paper›PMID 37759829›Full record

ArticleBiomolecules2023

Novel Biomarkers and Imaging Indices for the "Vulnerable Patient" with Carotid Stenosis: A Single-Center Study.

Nikolaos Kadoglou, Konstantinos G Moulakakis, George Mantas, Aris Spathis, Evangelia Gkougkoudi, Spyridon N Mylonas, John Kakisis, Christos Liapis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Nikolaos KadoglouMedical School, University of Cyprus, 2029 Nicosia, Cyprus.ORCID 0000-0002-7830-3488
Konstantinos G MoulakakisVascular Surgery Department, Patras University Hospital, University of Patras, Rio, 265 04 Patra, Greece.
George MantasDepartment of Vascular Surgery, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 115 27 Athens, Greece.
Aris Spathis2nd Department of Pathology, National and Kapodistrian University of Athens, 115 27 Athens, Greece.ORCID 0000-0001-8867-3661
Evangelia GkougkoudiMedical School, University of Cyprus, 2029 Nicosia, Cyprus.
Spyridon N MylonasDepartment of Vascular and Endovascular Surgery, University Hospital of Cologne, 50937 Cologne, Germany.ORCID 0000-0002-9875-4614
John KakisisDepartment of Vascular Surgery, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 115 27 Athens, Greece.
Christos LiapisDepartment of Vascular Surgery, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 115 27 Athens, Greece.
National and Kapodistrian University of Athens · GRUniversity of Cyprus · CYUniversity Hospital Cologne · DEUniversity of Patras · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated the relationship of matrix metalloproteinases (MMPs), cardio-ankle vascular index (CAVI), and Gray-Scale Median (GSM) score with the severity and vulnerability of carotid atherosclerosis and major adverse cardiovascular events (MACE) during follow-up of carotid artery revascularization.

methodsWe enrolled 262 patients undergoing carotid revascularization therapy (GRT), 109 asymptomatic patients with low-grade carotid stenosis (40-70%) receiving conservative treatment (GCT), and 92 age- and sex-matched control subjects without carotid atherosclerosis (GCO). All participants underwent carotid ultrasound and we assessed at baseline clinical parameters, metabolic profile, CAVI, GSM, and circulating levels of hsCRP, MMP-3,-7,-9, and TIMP-1.

resultsBoth GRT and GCT presented with elevated CAVI, MMPs, and TIMP-1 levels compared to GCO (

conclusionsNovel imaging and biochemical biomarkers were positively associated with atherosclerosis severity, while CAVI, MMP-9, and low GSM showed a positive, independent relationship with MACE after carotid revascularization, describing "vulnerable patients".

Indexed as

Carotid Artery DiseasesCarotid StenosisBiomarkersHumansMatrix Metalloproteinase 9Tissue Inhibitor of Metalloproteinase-1BiomarkersMatrix Metalloproteinase 9Tissue Inhibitor of Metalloproteinase-1cardio-ankle vascular indexcarotid atherosclerosiscarotid plaque instabilitymatrix metalloproteinasesvulnerable patient

Identifiers

PMID37759829
PMCPMC10526466
OpenAlexW4386911370

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.