Evidence map›Paper›PMID 37760589›Full record

ArticleCancers2023

Repurposing Clemastine to Target Glioblastoma Cell Stemness.

Michael A Sun, Rui Yang, Heng Liu, Wenzhe Wang, Xiao Song, Bo Hu, Nathan Reynolds, Kristen Roso, Lee H Chen, Paula K Greer and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. The use of antihistamine and antihistamine-like drugs for cancer-related pain: a narrative review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Michael A SunThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0003-3880-4787
Rui YangThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.
Heng LiuThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.
Wenzhe WangThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.
Xiao SongThe Ken & Ruth Davee Department of Neurology, Lou and Jean Malnati Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Simpson Querrey Institute for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-3171-4300
Bo HuThe Ken & Ruth Davee Department of Neurology, Lou and Jean Malnati Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Simpson Querrey Institute for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Nathan ReynoldsThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.
Kristen RosoThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.
Lee H ChenThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.
Paula K GreerThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.
Stephen T KeirThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.
Roger E McLendonThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0001-6682-4588
Shi-Yuan ChengThe Ken & Ruth Davee Department of Neurology, Lou and Jean Malnati Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Simpson Querrey Institute for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0003-1737-0588
Darell D BignerThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.
David M AshleyThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.
Christopher J PirozziThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.
Yiping HeThe Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.
Duke Medical Center · USNorthwestern University · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Laura Fish · 1985 to 2026
$174.8M
Targeting RNA Splicing in GliomaR01NS125318 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Shi-Yuan Cheng · 2022 to 2026
$2.4M
Role of Protein Methylation in Cell Mitosis and GlioblastomaR01NS115403 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHENG, SHI-YUAN · 2020 to 2024
$2.1M
Exploiting MTAP deletion for GBM therapeuticsR01NS101074 · NINDS · DUKE UNIVERSITY · PI HE, YIPING · 2017 to 2021
$1.7M
Cysteine Depletion-induced Ferroptosis as a Therapeutic Vulnerability iR21NS126810 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHENG, SHI-YUAN · 2022 to 2023
$440k
Targeting ATG4B to Treat GlioblastomaR21NS122375 · NINDS · NORTHWESTERN UNIVERSITY · PI CHENG, SHI-YUAN, SCHEIDT, KARL A · 2022 to 2023
$423k
NCI NIH HHS CA014236NCI NIH HHS P30 CA014236NINDS NIH HHS NS101074NINDS NIH HHS R01 NS101074NINDS NIH HHS R01 NS115403NINDS NIH HHS R01 NS125318NINDS NIH HHS R21 NS122375NINDS NIH HHS R21 NS126810
6 · The paper itself

Abstract

Brain tumor-initiating cells (BTICs) and tumor cell plasticity promote glioblastoma (GBM) progression. Here, we demonstrate that clemastine, an over-the-counter drug for treating hay fever and allergy symptoms, effectively attenuated the stemness and suppressed the propagation of primary BTIC cultures bearing

Indexed as

clemastineEmopamil Binding Protein (EBP)glioblastomastemness

Identifiers

PMID37760589
PMCPMC10526458
OpenAlexW4386860194

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.