Evidence map›Paper›PMID 37760920›Full record

ReviewBiomedicines2023

Clinical Perspectives of Gut Microbiota in Patients with Chronic Kidney Disease and End-Stage Kidney Disease: Where Do We Stand?

Alexandru Cosmin Pantazi, Mustafa Ali Kassim Kassim, Wassan Nori, Liliana Ana Tuta, Cristina Maria Mihai, Tatiana Chisnoiu, Adriana Luminita Balasa, Larisia Mihai, Ancuta Lupu, Corina Elena Frecus and 5 more

Abstract readReview
In one paragraph

Review in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Bridging Gaps in Long COVID Therapy: A Review.Current medicinal chemistry · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Gut Microbiota and Diabetes: Pioneering New Treatment Frontiers.Endocrine, metabolic & immune disorders drug targets · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alexandru Cosmin PantaziFaculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.ORCID 0000-0002-7234-2814
Mustafa Ali Kassim KassimFaculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.ORCID 0009-0009-5737-2634
Wassan NoriCollege of Medicine, Mustansiriyah University, Baghdad 10052, Iraq.ORCID 0000-0002-8749-2444
Liliana Ana TutaFaculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.
Cristina Maria MihaiFaculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.ORCID 0000-0001-8844-0593
Tatiana ChisnoiuFaculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.ORCID 0000-0002-4996-2484
Adriana Luminita BalasaFaculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.ORCID 0000-0002-5793-1370
Larisia MihaiFaculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.ORCID 0009-0006-5525-5408
Ancuta LupuFaculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0001-8147-3632
Corina Elena FrecusFaculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.
Vasile Valeriu LupuFaculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0003-2640-8795
Sergiu Ioachim ChirilaFaculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.ORCID 0000-0003-3275-2330
Anca Gabriela BadescuClinical Emergency Hospital of Constanta, 900591 Constanta, Romania.
Laurentiu-Tony HanganFaculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.
Simona Claudia CambreaFaculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.ORCID 0000-0003-4898-8938

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota (GM) plays a vital role in human health, with increasing evidence linking its imbalance to chronic kidney disease and end-stage kidney disease. Although the exact methods underlying kidney-GM crosstalk are not fully understood, interventions targeting GM were made and lay in three aspects: diagnostic, predictive, and therapeutic interventions. While these interventions show promising results in reducing uremic toxins and inflammation, challenges remain in the form of patient-specific GM variability, potential side effects, and safety concerns. Our understanding of GMs role in kidney disease is still evolving, necessitating further research to elucidate the causal relationship and mechanistic interactions. Personalized interventions focusing on specific GM signatures could enhance patient outcomes. However, comprehensive clinical trials are needed to validate these approaches' safety, efficacy, and feasibility.

Indexed as

dysbiosisgut microbiotakidney diseaseprobioticuremic toxin

Identifiers

PMID37760920
PMCPMC10525496

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.