Evidence map›Paper›PMID 37760978›Full record

ArticleBiomedicines2023

Anti-Hyperuricemic, Anti-Arthritic, Hemolytic Activity and Therapeutic Safety of Glycoconjugated Triazole-Phthalimides.

José Guedes da Silva, André de Lima Aires, Rebeca Xavier da Cunha, Talyta Valéria Siqueira do Monte, Shalom Pôrto de Oliveira Assis, Ronaldo Nascimento de Oliveira, Talita Giselly Dos Santos Souza, Cristiano Aparecido Chagas, Jacinto da Costa Silva Neto, Hallysson Douglas Andrade de Araújo and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Phthalimides as anti-inflammatory agents.Future medicinal chemistry · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

José Guedes da SilvaLaboratório de Lipídeos e Aplicações de Biomoléculas em Doenças Prevalentes e Negligenciadas (LAB-DPN), Centro de Biociências, Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife 50670-901, PE, Brazil.
André de Lima AiresCentro de Ciências Médicas-Área Acadêmica de Medicina Tropical, Universidade Federal de Pernambuco, Recife 50670-901, PE, Brazil.ORCID 0000-0001-9283-1466
Rebeca Xavier da CunhaLaboratório de Lipídeos e Aplicações de Biomoléculas em Doenças Prevalentes e Negligenciadas (LAB-DPN), Centro de Biociências, Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife 50670-901, PE, Brazil.
Talyta Valéria Siqueira do MonteCentro de Ciências da Saúde (CCS), Departamento de Enfermagem, Universidade Federal de Pernambuco, Recife 50670-901, PE, Brazil.
Shalom Pôrto de Oliveira AssisLaboratório de Biotecnologia e Ciências Ambientais (NPCIAMB), Departamento de Medicina, Universidade Católica de Pernambuco (UNICAP), Recife 50050-900, PE, Brazil.
Ronaldo Nascimento de OliveiraLaboratório de Síntese de Compostos Bioativos (LSCB), Departamento de Química, Universidade Federal Rural de Pernambuco (UFRPE), Recife 52171-900, PE, Brazil.ORCID 0000-0002-6111-2351
Talita Giselly Dos Santos SouzaLaboratório de Biotecnologia e Fármacos, Centro Acadêmico de Vitória (CAV), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil.
Cristiano Aparecido ChagasLaboratório de Biotecnologia e Fármacos, Centro Acadêmico de Vitória (CAV), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil.
Jacinto da Costa Silva NetoLaboratório de Pesquisas Citológicas e Moleculares (LPCM), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil.
Hallysson Douglas Andrade de AraújoLaboratório de Lipídeos e Aplicações de Biomoléculas em Doenças Prevalentes e Negligenciadas (LAB-DPN), Centro de Biociências, Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife 50670-901, PE, Brazil.ORCID 0000-0001-5150-1655
Vera Lúcia de Menezes LimaLaboratório de Lipídeos e Aplicações de Biomoléculas em Doenças Prevalentes e Negligenciadas (LAB-DPN), Centro de Biociências, Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife 50670-901, PE, Brazil.ORCID 0000-0003-2581-9218
Universidade Federal de Pernambuco · BRUniversidade Católica de Pernambuco · BRUniversidade Federal Rural de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperuricemia, the metabolic alteration that leads to gout or gouty arthritis, is increasing worldwide. Glycoconjugated triazole-phthalimides show potent anti-inflammatory activity. The aim of this study was to evaluate the anti-hyperuricemia effect of glycoconjugated triazole-phthalimides. To develop hyperuricemia, groups of mice received orally potassium oxonate (250 mg/kg) for 7 days, and

Indexed as

arthritisgouty arthritishyperuricemiamedicinal chemistryuric acid

Identifiers

PMID37760978
PMCPMC10526838
OpenAlexW4386778062

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.