Evidence map›Paper›PMID 37760981›Full record

ArticleBiomedicines2023

Systematic Exploration of Functional Group Relevance for Anti-Leishmanial Activity of Anisomycin.

Anh Minh Thao Nguyen, Moran Shalev-Benami, Chloé Rosa-Teijeiro, Ana Victoria Ibarra-Meneses, Ada Yonath, Anat Bashan, Charles L Jaffe, Martin Olivier, Christopher Fernandez-Prada, William D Lubell

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Anh Minh Thao NguyenDepartment of Chemistry, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Moran Shalev-BenamiDepartment of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Chloé Rosa-TeijeiroDepartment of Pathology and Microbiology, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.
Ana Victoria Ibarra-MenesesDepartment of Pathology and Microbiology, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.
Ada YonathDepartment of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Anat BashanDepartment of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Charles L JaffeDepartment of Microbiology & Molecular Genetics, Kuvin Center for the Study of Tropical & Infectious Diseases, Institute for Medical Research (IMRIC), Hadassah Hebrew University Medical Center, Jerusalem 9112102, Israel.
Martin OlivierDepartments of Medicine, and of Microbiology and Immunology, Faculty of Medicine, McGill University, Montreal, QC H3A 2B4, Canada.ORCID 0000-0002-3901-6638
Christopher Fernandez-PradaDepartment of Pathology and Microbiology, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0003-4834-4956
William D LubellDepartment of Chemistry, Université de Montréal, Montreal, QC H3T 1J4, Canada.ORCID 0000-0002-3080-2712
Université de Montréal · CAWeizmann Institute of Science · ILHadassah Medical Center · ILMcGill University Health Centre · CA

Funding

Canadian Institutes of Health Research grant #469305)New Frontiers in Research Fund Exploration Grant NFRFE-2018-00766The Canada Foundation for Innovation 37324the FRQNT Centre in Green Chemistry 171310the Natural Sciences and Engineering Research Council (NSERC) of Canada Discovery Grant Program Projects #06647the Natural Sciences and Engineering Research Council (NSERC) of Canada Discovery Grant Program Projects RGPIN-2017-04480
6 · The paper itself

Abstract

Assessment of structure-activity relationships for anti-protozoan activity revealed a strategy for preparing potent anisomycin derivatives with reduced host toxicity. Thirteen anisomycin analogs were synthesized by modifying the alcohol, amine, and aromatic functional groups. Examination of anti-protozoal activity against various strains of

Indexed as

anisomycinLeishmaniaribosome

Identifiers

PMID37760981
PMCPMC10526209
OpenAlexW4386777886

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.