Evidence map›Paper›PMID 37761806›Full record

SynthesisGenes2023

Interaction Analysis Reveals Complex Genetic Associations with Alzheimer's Disease in the

Alireza Nazarian, Brandon Cook, Marissa Morado, Alexander M Kulminski

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Genetic and environmental risk factors for dementia in African adults: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alireza NazarianBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA.ORCID 0000-0001-5810-6834
Brandon CookBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA.
Marissa MoradoBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA.ORCID 0000-0002-4011-3144
Alexander M KulminskiBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA.ORCID 0000-0002-0205-8228
Social Science Research Council · US

Funding

ApoE2 and protective molecular signatures in Alzheimer's disease and agingR01AG061853 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2018 to 2022
$3.9M
Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseasesR01AG065477 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2020 to 2024
$3.8M
Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic contextR01AG070488 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M, OUKRAINTSEVA, SVETLANA V. · 2020 to 2024
$2.8M
NIA NIH HHS R01 AG061853NIA NIH HHS R01AG061853; R01AG065477; R01AG070488NIA NIH HHS R01 AG065477NIA NIH HHS R01 AG070488
6 · The paper itself

Abstract

Sporadic Alzheimer's disease (AD) is a polygenic neurodegenerative disorder. Single-nucleotide polymorphisms (SNPs) in multiple genes (e.g.,

Indexed as

Alzheimer DiseaseATP-Binding Cassette TransportersClusterinGenetic Predisposition to DiseaseEpistasis, GeneticHumansPolymorphism, Single NucleotideABCA7 protein, humanATP-Binding Cassette TransportersCLU protein, humanClusterinAgingcompound genotypedementiagenetic heterogeneitySNPs interaction

Identifiers

PMID37761806
PMCPMC10531324
OpenAlexW4386098176

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.