Evidence map›Paper›PMID 37762000›Full record

ArticleInternational journal of molecular sciences2023

Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain.

Oxana Semyachkina-Glushkovskaya, Sergey Sokolovski, Ivan Fedosov, Alexander Shirokov, Nikita Navolokin, Alla Bucharskaya, Inna Blokhina, Andrey Terskov, Alexander Dubrovski, Valeria Telnova and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 5 countries.

Oxana Semyachkina-GlushkovskayaPhysics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany.ORCID 0000-0001-6753-7513
Sergey SokolovskiOptoelectronics and Biomedical Photonics Group, AIPT, Aston University, Birmingham B4 7ET, UK.ORCID 0000-0001-7445-7204
Ivan FedosovPhysics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Alexander ShirokovDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.ORCID 0000-0003-4321-735X
Nikita NavolokinDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.ORCID 0000-0001-7876-9758
Alla BucharskayaDepartment of Pathological Anatomy, Saratov Medical State University, Bolshaya Kazachaya Str. 112, 410012 Saratov, Russia.ORCID 0000-0003-0503-6486
Inna BlokhinaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.ORCID 0000-0003-1517-0857
Andrey TerskovDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Alexander DubrovskiPhysics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Valeria TelnovaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.ORCID 0000-0001-8411-6366
Anna TzvenDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Maria TzoyPhysics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.ORCID 0000-0002-4681-6465
Arina EvsukovaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Daria ZhlatogosrkayaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Viktoria AdushkinaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Alexander DmitrenkoDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Maria ManzhaevaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Valeria KrupnovaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Alessio NogheroLovelace Biomedical Research Institute, Albuquerque, NM 87108, USA.
Denis BraginLovelace Biomedical Research Institute, Albuquerque, NM 87108, USA.ORCID 0000-0003-4894-0061
Olga BraginaLovelace Biomedical Research Institute, Albuquerque, NM 87108, USA.
Ekaterina BorisovaInstitute of Electronics, Bulgarian Academy of Sciences, Tsarigradsko Chaussee Blvd. 72, 1784 Sofia, Bulgaria.ORCID 0000-0002-4844-6066
Jürgen KurthsPhysics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany.
Edik RafailovOptoelectronics and Biomedical Photonics Group, AIPT, Aston University, Birmingham B4 7ET, UK.ORCID 0000-0002-4152-0120
Saratov State University · RULovelace Respiratory Research Institute · USAston University · GBBulgarian Academy of Sciences · BGSaratov State Medical University · RU

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
Brain Injury Treatment by Modulation of Hemodynamics With Blood Soluble Drag Reducing MoleculesR01NS112808 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2019 to 2023
$2.1M
Stroke Treatment by Modulation of Hemodynamics with Drag Reducing MoleculesR21NS091600 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2015 to 2016
$423k
NIGMS NIH HHS P20 GM109089NINDS NIH HHS R01 NS112808NINDS NIH HHS R21 NS091600
6 · The paper itself

Abstract

Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the most lethal form of brain cancer, with very limited treatment options and a poor prognosis. In this study on rats, we demonstrate that glioblastoma (GBM) growth can be suppressed by photosensitizer-free laser treatment (PS-free-LT) using a quantum-dot-based 1267 nm laser diode. This wavelength, highly absorbed by oxygen, is capable of turning triplet oxygen to singlet form. Applying 1267 nm laser irradiation for a 4 week course with a total dose of 12.7 kJ/cm

Indexed as

Brain NeoplasmsGlioblastomaAnimalsApoptosisBrainCell Line, TumorCell ProliferationHumansLaser TherapyMalePhotosensitizing AgentsQuantum DotsRatsPhotosensitizing Agentsglioblastomalymphatic systemNIR laser oxidative cell damagingphototherapyquantum-dot 1267 nm laser

Identifiers

PMID37762000
PMCPMC10530910
OpenAlexW4386443486

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.