Evidence map›Paper›PMID 37762003›Full record

ArticleInternational journal of molecular sciences2023

Redox-Sensitive Delivery of Doxorubicin from Nanoparticles of Poly(ethylene glycol)-Chitosan Copolymer for Treatment of Drug-Resistant Oral Cancer Cells.

Kaengwon Yoon, Seunggon Jung, Jaeyoung Ryu, Hong-Ju Park, Hee-Kyun Oh, Min-Suk Kook

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kaengwon YoonEl-Dental Clinic, Seomun Daero Street 625, Namgu, Gwangju 61737, Republic of Korea.
Seunggon JungDepartment of Maxillofacial Oral Surgery, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea.
Jaeyoung RyuDepartment of Maxillofacial Oral Surgery, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea.ORCID 0000-0002-2940-5875
Hong-Ju ParkDepartment of Maxillofacial Oral Surgery, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea.
Hee-Kyun OhDepartment of Maxillofacial Oral Surgery, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea.
Min-Suk KookDepartment of Maxillofacial Oral Surgery, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea.ORCID 0000-0002-8053-8534
Chonnam National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen species (ROS)-sensitive polymer nanoparticles were synthesized for tumor targeting of an anticancer drug, doxorubicin (DOX). For this purpose, chitosan-methoxy poly(ethylene glycol) (mPEG) (ChitoPEG)-graft copolymer was synthesized and then DOX was conjugated to the backbone of chitosan using a thioketal linker. Subsequently, the chemical structure of the DOX-conjugated ChitoPEG copolymer (ChitoPEGthDOX) was confirmed via

Indexed as

ChitosanDoxorubicinDrug Resistance, NeoplasmMouth NeoplasmsNanoparticlesPolyethylene GlycolsAnimalsAntibiotics, AntineoplasticCell Line, TumorDrug CarriersDrug Delivery SystemsHumansMiceOxidation-ReductionReactive Oxygen SpeciesAntibiotics, AntineoplasticChitosanDoxorubicinDrug CarriersPolyethylene GlycolsReactive Oxygen Speciesdoxorubicindrug-resistantnanoparticlesoral squamous carcinoma cellsROS-sensitive drug delivery

Identifiers

PMID37762003
PMCPMC10531032
OpenAlexW4386443670

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.