Evidence map›Paper›PMID 37762137›Full record

ArticleInternational journal of molecular sciences2023

Cystatin SN (CST1) as a Novel Salivary Biomarker of Periodontitis.

Federica Romano, Francesco Franco, Matteo Corana, Giuliana Abbadessa, Federica Di Scipio, Barbara Pergolizzi, Chiara Castrignano, Mario Aimetti, Giovanni N Berta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Federica RomanoDepartment of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-5172-299X
Francesco FrancoDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.ORCID 0009-0005-8527-9980
Matteo CoranaDepartment of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, 10126 Turin, Italy.
Giuliana AbbadessaDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.
Federica Di ScipioDepartment of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, 10126 Turin, Italy.
Barbara PergolizziDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.ORCID 0000-0003-4686-0068
Chiara CastrignanoDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.ORCID 0009-0001-9029-9186
Mario AimettiDepartment of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, 10126 Turin, Italy.
Giovanni N BertaDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.ORCID 0000-0002-3263-9349
University of Turin · IT

Funding

RILO 2021 Universita' degli Studi di Torino RILO 2021 Universita' degli Studi di Torino
6 · The paper itself

Abstract

Identification of biomarkers could help in assessing periodontal health status and monitoring treatment outcomes. Therefore, the aim of this cross-sectional study was to identify potential innovative salivary biomarkers for the diagnosis of periodontitis using an untargeted proteomic approach. Forty-five healthy non-smoker participants diagnosed as having periodontally healthy conditions (H), severe periodontitis (P), and healthy but reduced periodontium after active periodontal treatment (T) were consecutively enrolled (15 per each group) in the study. A higher number of spots were identified in the proteome of unstimulated whole saliva collected from H and T subjects compared with P group, mainly within the range of 8-40 kDa. Protein spots of interest were analysed by MALDI-TOF-MS, allowing the identification of cystatin SN (CST1) isoform, as confirmed by Western blot. CST1 was markedly expressed in the H group, while it was absent in most P samples (

Indexed as

BiomarkersPeriodontitisSalivaSalivary CystatinsAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedProteomicsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationBiomarkersCST1 protein, humanSalivary Cystatinscystatin SNmass spectrometryperiodontal diagnosisperiodontitissalivauntargeted proteomics

Identifiers

PMID37762137
PMCPMC10530756
OpenAlexW4386559005

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.