Evidence map›Paper›PMID 37762174›Full record

ArticleInternational journal of molecular sciences2023

Medermycin Inhibits TNFα-Promoted Inflammatory Reaction in Human Synovial Fibroblasts.

Sho Inoue, Yuki Inahashi, Makoto Itakura, Gen Inoue, Kyoko Muneshige, Tomoyasu Hirose, Masato Iwatsuki, Masashi Takaso, Masayuki Miyagi, Kentaro Uchida

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sho InoueDepartment of Orthopedic Surgery, Kitasato University School of Medicine, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Japan.
Yuki InahashiGraduate School of Infection Control Sciences, Kitasato University, 5-9-1 Minato-ku Shirokane, Tokyo 108-8641, Japan.
Makoto ItakuraDepartment of Biochemistry, Kitasato University School of Medicine, 1-15-1 Minami-ku, Kitasato, Sagamihara City 252-0374, Japan.
Gen InoueDepartment of Orthopedic Surgery, Kitasato University School of Medicine, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Japan.ORCID 0000-0001-6500-9004
Kyoko MuneshigeDepartment of Orthopedic Surgery, Kitasato University School of Medicine, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Japan.
Tomoyasu HiroseGraduate School of Infection Control Sciences, Kitasato University, 5-9-1 Minato-ku Shirokane, Tokyo 108-8641, Japan.ORCID 0000-0002-9463-8181
Masato IwatsukiGraduate School of Infection Control Sciences, Kitasato University, 5-9-1 Minato-ku Shirokane, Tokyo 108-8641, Japan.ORCID 0000-0001-8373-4314
Masashi TakasoDepartment of Orthopedic Surgery, Kitasato University School of Medicine, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Japan.
Masayuki MiyagiDepartment of Orthopedic Surgery, Kitasato University School of Medicine, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Japan.ORCID 0000-0002-3082-9739
Kentaro UchidaDepartment of Orthopedic Surgery, Kitasato University School of Medicine, 1-15-1 Minami-ku Kitasato, Sagamihara City 252-0374, Japan.ORCID 0000-0001-5148-914X
Kitasato University · JPKitasato Institute Hospital · JPShonan University of Medical Sciences · JP

Funding

All Kitasato Project Study (AKPS) noneJSPS KAKENHI 23K08617Research Support Project for Life Sciences Research and Drug Discovery, specifically the Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS) JP22ama121035
6 · The paper itself

Abstract

Synovial inflammation plays a crucial role in the destruction of joints and the experience of pain in osteoarthritis (OA). Emerging evidence suggests that certain antibiotic agents and their derivatives possess anti-inflammatory properties. Medermycin (MED) has been identified as a potent antibiotic, specifically active against Gram-positive bacteria. In this study, we aimed to investigate the impact of MED on TNFα-induced inflammatory reactions in a synovial cell line, SW-982, as well as primary human synovial fibroblasts (HSF) using RNA sequencing, rtRT-PCR, ELISA, and western blotting. Through the analysis of differentially expressed genes (DEGs), we identified a total of 1478 significantly upregulated genes in SW-982 cells stimulated with TNFα compared to the vehicle control. Among these upregulated genes, MED treatment led to a reduction in 1167 genes, including those encoding proinflammatory cytokines such as

Indexed as

OsteoarthritisTumor Necrosis Factor-alphaAnti-Bacterial AgentsBenzoisochromanequinonesCytokinesFibroblastsHumansInflammationInterleukin-6Interleukin-8NaphthoquinonesAnti-Bacterial AgentsBenzoisochromanequinonesCytokinesInterleukin-6Interleukin-8medermycinNaphthoquinonesTumor Necrosis Factor-alphamedermycinNFκBosteoarthritissynovial fibroblastTNF-α

Identifiers

PMID37762174
PMCPMC10531480
OpenAlexW4386602490

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.