Evidence map›Paper›PMID 37762178›Full record

ArticleInternational journal of molecular sciences2023

Investigating the Role of Serum and Plasma IL-6, IL-8, IL-10, TNF-alpha, CRP, and S100B Concentrations in Obstructive Sleep Apnea Diagnosis.

Piotr Fiedorczuk, Ewa Olszewska, Agnieszka Polecka, Marzena Walasek, Barbara Mroczko, Agnieszka Kulczyńska-Przybik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
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  4. Mechanisms Linking Sleep-Disordered Breathing and Cardiometabolic Disease Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Piotr FiedorczukDepartment of Otolaryngology, Medical University of Bialystok, 15-089 Bialystok, Poland.ORCID 0000-0002-7039-0951
Ewa OlszewskaDepartment of Otolaryngology, Medical University of Bialystok, 15-089 Bialystok, Poland.ORCID 0000-0002-9993-9266
Agnieszka PoleckaDoctoral School of the Medical, University of Bialystok, 15-089 Bialystok, Poland.ORCID 0000-0002-5077-8553
Marzena WalasekDepartment of Otolaryngology, Medical University of Bialystok, 15-089 Bialystok, Poland.
Barbara MroczkoDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok 15-089 Bialystok, Poland.ORCID 0000-0002-4075-8479
Agnieszka Kulczyńska-PrzybikDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok 15-089 Bialystok, Poland.
Medical University of Białystok · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) is a prevalent and underdiagnosed condition associated with cardiovascular diseases, depression, accidents, and stroke. There is an increasing need for alternative diagnostic tools beyond overnight sleep studies that measure the Apnea/Hypopnea Index (AHI). In this single-center, case-control study, we evaluated serum and plasma concentrations of IL-6, IL-8, IL-10, TNF-α, CRP, and S100B in 80 subjects, including 52 OSA patients (27 moderate [15 ≤ AHI ˂ 30], 25 severe [AHI ≥ 30]) and 28 non-OSA controls (AHI 0-5). Participants with OSA showed approximately 2 times higher median concentrations of CRP in plasma, and IL-6 in serum, as well as 1.3 to 1.7 times higher concentrations of TNF-α and IL-8 in plasma compared with the control group. Receiver Operator Characteristic (ROC) curve analysis was performed to evaluate the predictive capabilities of these serum and plasma biomarkers in distinguishing between the OSA and control groups, revealing varying sensitivity and specificity. In summary, in this study, serum and plasma biomarkers CRP, S100B, IL-6, TNF-α, and IL-8 have been shown to be elevated in patients with OSA, correlated positively with disease severity, age, and BMI. These results support the potential role of these biomarkers in diagnosing OSA, supplementing traditional methods such as overnight sleep studies.

Indexed as

C-Reactive ProteinS100 Calcium Binding Protein beta SubunitSleep Apnea, ObstructiveTumor Necrosis Factor-alphaAdultAgedBiomarkersCase-Control StudiesFemaleHumansInterleukin-10Interleukin-6Interleukin-8MaleMiddle AgedROC CurveBiomarkersC-Reactive ProteinCXCL8 protein, humanIL10 protein, humanIL6 protein, humanInterleukin-10Interleukin-6Interleukin-8S100B protein, humanS100 Calcium Binding Protein beta SubunitTumor Necrosis Factor-alphabiomarkersobstructive sleep apneaplasma and serum concentrations

Identifiers

PMID37762178
PMCPMC10530258
OpenAlexW4386603123

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.