Evidence map›Paper›PMID 37762276›Full record

ArticleInternational journal of molecular sciences2023

Positive Allosteric Modulators of SERCA Pump Restore Dendritic Spines and Rescue Long-Term Potentiation Defects in Alzheimer's Disease Mouse Model.

Anastasiya Rakovskaya, Alexander Erofeev, Egor Vinokurov, Ekaterina Pchitskaya, Russell Dahl, Ilya Bezprozvanny

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Neuronal Calcium Signaling and Cytoskeletal Dynamics in Neurodegeneration.International journal of molecular sciences · 2026
    Review
  6. Article
  7. Review
  8. SERCA Silencing Alleviates AßInternational journal of molecular sciences · 2025
    Article
  9. Article
  10. Neurodegenerative Disease: From Molecular Basis to Therapy, 2nd Edition.International journal of molecular sciences · 2025
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Anastasiya RakovskayaLaboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnical University, St. Petersburg 195251, Russia.
Alexander ErofeevLaboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnical University, St. Petersburg 195251, Russia.ORCID 0000-0003-3814-9831
Egor VinokurovLaboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnical University, St. Petersburg 195251, Russia.ORCID 0009-0006-8248-3983
Ekaterina PchitskayaLaboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnical University, St. Petersburg 195251, Russia.
Russell DahlNeurodon Corporation, 9800 Connecticut Drive, Crown Point, IN 46307, USA.
Ilya BezprozvannyLaboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnical University, St. Petersburg 195251, Russia.ORCID 0000-0001-7006-6951
Peter the Great St. Petersburg Polytechnic University · RU

Funding

Calcium dysregulation and vulnerability of entorhinal cortex neurons in Alzheimer's diseaseR01AG071310 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI James S Malter · 2023 to 2026
$2.9M
Optimization of small molecule SERCA2b activators to inhibit neuron loss in Alzheimer's diseaseR42AG062001 · NIA · NEURODON LLC · PI DAHL, RUSSELL · 2020 to 2021
$2.0M
Optimization of small molecule SERCA2b activators to inhibit neuron loss in Alzheimer's diseaseR44AG062001 · NIA · NEURODON LLC · PI DAHL, RUSSELL · 2023 to 2024
$1.2M
NIA NIH HHS R01 AG071310NIA NIH HHS R42 AG062001NIA NIH HHS R44 AG062001
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that affects memory formation and storage processes. Dysregulated neuronal calcium (Ca

Indexed as

Alzheimer DiseaseAnimalsDendritic SpinesDisease Models, AnimalEndoplasmic ReticulumHEK293 CellsHumansLong-Term PotentiationMiceMice, TransgenicAlzheimer’s diseasebeta-amyloidcalciumcalcium imagingdendritic spineslong-term potentiationpositive allosteric modulatorsSERCA

Identifiers

PMID37762276
PMCPMC10530588
OpenAlexW4386638965

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.