Evidence map›Paper›PMID 37762297›Full record

ArticleInternational journal of molecular sciences2023

Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice.

Natalia Jermakow, Weronika Skarżyńska, Katarzyna Lewandowska, Ewelina Kiernozek, Katarzyna Goździk, Anna Mietelska-Porowska, Nadzieja Drela, Urszula Wojda, Maria Doligalska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Natalia JermakowFaculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warszawa, Poland.ORCID 0000-0001-5639-2603
Weronika SkarżyńskaFaculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warszawa, Poland.
Katarzyna LewandowskaFaculty of Chemistry, Nicolaus Copernicus in Toruń, Gagarina 7, 87-100 Toruń, Poland.ORCID 0000-0002-8380-4009
Ewelina KiernozekFaculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warszawa, Poland.
Katarzyna GoździkFaculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warszawa, Poland.ORCID 0000-0002-7051-9524
Anna Mietelska-PorowskaLaboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology, Ludwika Pasteura 3, 02-093 Warszawa, Poland.ORCID 0000-0002-3192-8739
Nadzieja DrelaFaculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warszawa, Poland.ORCID 0000-0002-9981-1553
Urszula WojdaLaboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology, Ludwika Pasteura 3, 02-093 Warszawa, Poland.ORCID 0000-0002-4525-2004
Maria DoligalskaFaculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warszawa, Poland.ORCID 0000-0002-3175-4564
University of Warsaw · PLInstytut Biologii Doświadczalnej im. Marcelego Nenckiego · PLNicolaus Copernicus University · PL

Funding

National Science Center Grant No. 2014/15/D/NZ4/04361Polish Research Council for the University of Warsaw Grant No.500-D114-11-1140800Polish Research Council for the University of Warsaw Grant No.501-D114-01-1140800
6 · The paper itself

Abstract

Parasitic helminths induce a transient, short-term inflammation at the beginning of infection, but in persistent infection may suppress the systemic immune response by enhancing the activity of regulatory M2 macrophages. The aim of the study was to determine how nematode infection affects age-related neuroinflammation, especially macrophages in the nervous tissue. Here, intraperitoneal LPS-induced systemic inflammation resulting in brain neurodegeneration was enhanced by prolonged

Indexed as

AgingLipopolysaccharidesAnimalsHelminthiasisInflammationIntestinal Diseases, ParasiticMiceMice, Inbred C57BLLipopolysaccharidesageinghelminthsimmunomodulationneurobehavioural manifestationsneurodegenerative diseasesneuroinflammationpersistent infection

Identifiers

PMID37762297
PMCPMC10530578
OpenAlexW4386629294

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.