ArticleLife (Basel, Switzerland)2023
AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study.
Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Admission APRI and Early Mortality in ICU Patients with Sepsis: A Retrospective Cohort Study.Microorganisms · 2026Article
- A Predictive Model for Cytomegalovirus Infection Using Routine Hematological and Biochemical Parameters:Saudi medical journal · 2026Article
- Chronic hepatitis B with type 2 diabetes mellitus: Association between glycemic control and liver fibrosis.World journal of diabetes · 2025Article
- An Exploration of Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) Platelet Ratio Index (APRI) Scores with Dysglycemia and Diabetic Retinopathy: The Beichen Eye Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Elevated Alanine Transaminase-to-Platelet Index (APRI) Is Associated with Obesity and Distinct Forms of Dyslipidemia: A Retrospective Cross-Sectional Study.Journal of clinical medicine · 2024Article
- The Hepatoprotective Effects ofLife (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundHyperglycemia is a common symptom of numerous conditions, most notably diabetes mellitus and Cushing's syndrome, and the liver plays a pivotal role in the regulation of glucose metabolism. The AST-platelet ratio index (AST APRI score) and ALT-platelet ratio index (ALT APRI score) are novel parameters whose association with circulating glucose levels remains poorly studied.
methodsLaboratory data of 14,177 subjects were retrospectively analyzed for the association between AST and ALT APRI scores and fasting blood glucose (FBG) using the Mann-Whitney U and Kruskal-Wallis tests, Spearman's rank correlation coefficient, prevalence and odds ratio (OR) and ROC curve analysis.
resultsAST and ALT APRI scores showed progressive increases with FBG, and the mean FBG was significantly higher in subjects with high AST (104.9 ± 0.33 to 120.8 ± 3.27,
conclusionsThe AST and ALT APRI scores are inexpensive, novel markers of FBG and may serve as supportive evidence in the diagnosis and management of hyperglycemic conditions.
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