Evidence map›Paper›PMID 37764741›Full record

ArticleNutrients2023

The Epigenetic Legacy of Maternal Protein Restriction: Renal

Huijuan Jia, Moe Miyoshi, Xuguang Li, Kyohei Furukawa, Lila Otani, Katsuhiko Shirahige, Fumihito Miura, Takashi Ito, Hisanori Kato

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Huijuan JiaHealth Nutrition, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.ORCID 0000-0002-9920-8340
Moe MiyoshiHealth Nutrition, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Xuguang LiHealth Nutrition, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.ORCID 0009-0002-6309-6663
Kyohei FurukawaHealth Nutrition, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.ORCID 0000-0002-0226-1277
Lila OtaniHealth Nutrition, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Katsuhiko ShirahigeResearch Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-0032, Japan.
Fumihito MiuraDepartment of Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Takashi ItoDepartment of Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Hisanori KatoHealth Nutrition, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
The University of Tokyo · JPKyushu University · JPNagoya University · JP

Funding

Japan Agency for Medical Research and Development JP21am0101103Japan Society for the Promotion of Science 17H03815
6 · The paper itself

Abstract

Nutrient imbalances during gestation are a risk factor for hypertension in offspring. Although the effects of prenatal nutritional deficiency on the development of hypertension and cardiovascular diseases in adulthood have been extensively documented, its underlying mechanisms remain poorly understood. In this study, we aimed to elucidate the precise role and functional significance of epigenetic modifications in the pathogenesis of hypertension. To this end, we integrated methylome and transcriptome data to identify potential salt-sensitive hypertension genes using the kidneys of stroke-prone spontaneously hypertensive rat (SHRSP) pups exposed to a low-protein diet throughout their fetal life. Maternal protein restriction during gestation led to a positive correlation between DNA hypermethylation of the renal prostaglandin E receptor 1 (

Indexed as

HypertensionMaternal Nutritional Physiological PhenomenaPrenatal Exposure Delayed EffectsReceptors, Prostaglandin E, EP1 SubtypeAnimalsDiet, Protein-RestrictedDNADNA MethylationEpigenesis, GeneticFemaleKidneyPregnancyRatsRats, Inbred SHRDNAPtger1 protein, ratReceptors, Prostaglandin E, EP1 SubtypeDNA methylationepigeneticshypertensionkidneylow protein dietmaternal nutritionnutrigenomicsoffspringpostnatal nutritionPtger1

Identifiers

PMID37764741
PMCPMC10535296
OpenAlexW4386713081

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.