Evidence map›Paper›PMID 37764756›Full record

ArticleNutrients2023

Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells.

Ming-Chang Tsai, Ching-Chun Chen, Tsui-Hwa Tseng, Yun-Ching Chang, Yi-Jie Lin, I-Ning Tsai, Chi-Chih Wang, Chau-Jong Wang

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  5. Review
  6. Intratumoral administration ofFrontiers in immunology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ming-Chang TsaiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Ching-Chun ChenInstitute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
Tsui-Hwa TsengDepartment of Medical Applied Chemistry, Chung Shan Medical University, Taichung 402, Taiwan.
Yun-Ching ChangDepartment of Health Industry Technology Management, Chung Shan Medical University, Taichung 402, Taiwan.ORCID 0000-0003-4998-3338
Yi-Jie LinDepartment of Health Industry Technology Management, Chung Shan Medical University, Taichung 402, Taiwan.
I-Ning TsaiInstitute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
Chi-Chih WangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan.ORCID 0000-0002-8222-0503
Chau-Jong WangDepartment of Health Industry Technology Management, Chung Shan Medical University, Taichung 402, Taiwan.
Chung Shan Medical University · TWChung Shan Medical University Hospital · TW

Funding

Chung Shan Medical University Hospital CSH-2023-C-007Ministry of Science and Technology MOST 111-2320-B-040-025
6 · The paper itself

Abstract

Apoptosis, a programmed cell death process preventing cancer development, can be evaded by cancer cells. AMP-activated protein kinase (AMPK) regulates energy levels and is a key research topic in cancer prevention and treatment. Some bioactive components of

Indexed as

AMP-Activated Protein KinasesAnthocyaninsAntineoplastic Agents, PhytogenicApoptosisColorectal NeoplasmsHibiscusPlant ExtractsCaspase 3Caspase 8Cell Line, TumorCytochromes cEnzyme ActivationHumansMitochondriaSignal TransductionAMP-Activated Protein KinasesAnthocyaninsAntineoplastic Agents, PhytogenicCaspase 3Caspase 8Cytochromes cPlant ExtractsAMPKapoptosiscolorectal cancerFas/Fas LHibiscus anthocyanidin extract

Identifiers

PMID37764756
PMCPMC10535221
OpenAlexW4386782526

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.