Evidence map›Paper›PMID 37767892›Full record

ArticleeLife2023

An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity.

Niraja Ramesh, Marc Escher, Oriane Turrel, Janine Lützkendorf, Tanja Matkovic, Fan Liu, Stephan J Sigrist

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Active zone plasticity couples sleep need to presynaptic hypophosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Presynaptic regulators in memory formation.Learning & memory (Cold Spring Harbor, N.Y.) · 2024
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Niraja RameshInstitute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-7099-4093
Marc EscherInstitute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany.
Oriane TurrelInstitute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0003-2174-7659
Janine LützkendorfInstitute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0001-5051-6281
Tanja MatkovicInstitute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany.
Fan LiuLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Stephan J SigristInstitute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-1698-5815
Freie Universität Berlin · DELeibniz-Forschungsinstitut für Molekulare Pharmakologie · DE

Funding

European Research Council [ERC-AdG "Synprotect"]European Research Council [ERC-AdG Synprotect"]"
6 · The paper itself

Abstract

We still face fundamental gaps in understanding how molecular plastic changes of synapses intersect with circuit operation to define behavioral states. Here, we show that an antagonism between two conserved regulatory proteins, Spinophilin (Spn) and Syd-1, controls presynaptic long-term plasticity and the maintenance of olfactory memories in

Indexed as

Drosophila melanogasterDrosophila ProteinsMemoryMicrofilament ProteinsNerve Tissue ProteinsNeuronal PlasticityPresynaptic TerminalsAnimalsMushroom BodiesDrosophila ProteinsMicrofilament ProteinsNerve Tissue Proteinsactive zoneD. melanogasterhomeostasismemoryneuroscienceneurotransmissionplasticitypresynaptic plasticity

Identifiers

PMID37767892
PMCPMC10588984
OpenAlexW4387115605

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.