Evidence map›Paper›PMID 37768460›Full record

ArticleBulletin of experimental biology and medicine2023

Changes in the Number of Residual γH2AX Foci in Ki-67-Positive and Ki-67-Negative Human Fibroblasts Irradiated with X-Rays in Doses of 2-10 Gy.

N Yu Vorobyeva, A A Osipov, A K Chigasova, E I Yashkina, A N Osipov

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Article in Bulletin of experimental biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

N Yu VorobyevaN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
A A OsipovN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
A K ChigasovaN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
E I YashkinaN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
A N OsipovN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia. andreyan.osipov@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied changes in the number of residual γH2AX foci in cultured human fibroblasts with different expression of the cell proliferation marker protein Ki-67 24, 48, and 72 h after exposure to X-ray radiation in doses of 2-10 Gy. It was shown that, regardless of the expression of Ki-67, the number of residual γH2AX foci in irradiated cells linearly depends on the absorbed dose of X-ray radiation. However, the quantitative yield of residual γH2AX foci per unit of the absorbed dose in Ki-67

Indexed as

DNA RepairHistonesDose-Response Relationship, RadiationFibroblastsHumansKi-67 AntigenX-RaysHistonesKi-67 Antigencell proliferationDNA double-strand breakshuman fibroblastsresidual γH2AX fociX-ray radiation

Identifiers

PMID37768460

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.