Evidence map›Paper›PMID 37770263›Full record

ArticleBMJ open2023

EMBIO trial study protocol: left gastric artery embolisation for weight loss in patients living with obesity with a BMI 35-50 kg/m

Prashant Patel, Robert Thomas, Mohamad Hamady, Julian Hague, Jowad Raja, Tricia Tan, Stephen Bloom, Toby Richards, Clifford R Weiss, Christina Gabriele Prechtl and 7 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Prashant PatelDepartment of Cancer and Surgery, Imperial College London - St Mary's Campus, London, UK prashant.patel05@imperial.ac.uk.ORCID 0000-0002-1708-0292
Robert ThomasDepartment of Interventional Radiology, University College London Hospitals NHS Foundation Trust, London, UK.
Mohamad HamadySurgery and Cancer, Imperial College London, London, UK.
Julian HagueDepartment of Interventional Radiology, University College London Hospitals NHS Foundation Trust, London, UK.
Jowad RajaDepartment of Interventional Radiology, University College London Hospitals NHS Foundation Trust, London, UK.
Tricia TanDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0001-5873-3432
Stephen BloomClinical Director, North West London Pathology, Head of Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Hammersmith Hospital, London, UK.
Toby RichardsDepartment of Cancer and Surgery, The University of Western Australia, Perth, Western Australia, Australia.
Clifford R WeissRadiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Christina Gabriele PrechtlDepartment of Public Health, Imperial College Healthcare NHS Trust, London, UK.
Claire SmithImperial Clinical Trials Unit, Imperial College London, London, UK.
Thiagarajah SasikaranImperial College Clinical Trials Unit, Imperial College London, London, UK.
Richard HeskethDepartment of Interventional Radiology, University College London Hospitals NHS Foundation Trust, London, UK.
Elli BourmpakiDepartment of Interventional Radiology, University College London Hospitals NHS Foundation Trust, London, UK.
Nicholas Andrew JohnsonDepartment of Public Health, Imperial College Healthcare NHS Trust, London, UK.ORCID 0000-0002-3702-5530
Francesca FiorentinoInterventional Radiology, Imperial College Healthcare NHS Trust, London, UK.
Ahmed R AhmedDepartment of Cancer and Surgery, Imperial College London, London, UK.
University College London Hospitals NHS Foundation Trust · GBImperial College Healthcare NHS Trust · GBImperial College London · GBHammersmith Hospital · GBJohns Hopkins University · USThe University of Western Australia · AU

Funding

Department of Health 17/11/49Medical Research Council
6 · The paper itself

Abstract

introductionLeft gastric artery embolisation (LGAE) is a well-established treatment for major upper gastrointestinal (GI) bleeding when control is not established via upper GI endoscopy and recently has shown promising results for weight loss in small single arm studies. LGAE could be a treatment option in between our current tier-3 and tier-4 services for obesity. EMBIO is a National Institute for Health Research funded trial, a multicentre double-blinded randomised controlled trial between Imperial College National Health Service Trust and University College London Hospital, comparing LGAE versus Placebo procedure. The key aims of the trial is to evaluate LGAE efficacy on weight loss, its mechanism of action, safety profile and obesity-related comorbidities. METHODS AND ANALYSIS: 76 participants will be recruited from the existing tier-3 database after providing informed consent. Key inclusion criteria include adults aged 18-70 with a body mass index 35-50 kg/m ETHICS AND DISSEMINATION: This trial shall be conducted in full conformity with the 1964 Declaration of Helsinki and all subsequent revisions. Local research ethics approval was granted by London-Central Research Ethics Committee, (Reference 19/LO/0509) on 11 October 2019. The Medicines and Healthcare products Regulatory Agency (MHRA) issued the Letter of No Objection on 8 April 2022 (Reference CI/2022/0008/GB). The trial's development and progress are monitored by an independent trial steering committee and data monitoring and ethics committee. The researchers plan to disseminate results at conferences, in peer- reviewed journals as well as lay media and to patient organisations. TRIAL REGISTRATION NUMBER: ISRCTN16158402.

Indexed as

COVID-19Diabetes Mellitus, Type 2AdultBody Mass IndexGastric ArteryHumansMulticenter Studies as TopicObesityRandomized Controlled Trials as TopicSARS-CoV-2State MedicineTreatment OutcomeWeight LossBariatric SurgeryInterventional radiologyObesity

Identifiers

PMID37770263
PMCPMC10546152
OpenAlexW4387143157

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.