ArticleNature cardiovascular research2023
Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature cardiovascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Interleukin-receptor antagonist and tumour necrosis factor inhibitors for the primary and secondary prevention of atherosclerotic cardiovascular diseases.The Cochrane database of systematic reviews · 2024Pooled it
- Gene regulatory network analysis identifies auranofin as an anti-atherosclerotic drug.Nature communications · 2026Article
- Reprogramming macrophage metabolism for cardiovascular therapy: From molecular pathways to precision nanomedicine.Materials today. Bio · 2026Review
- Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs.PLoS pathogens · 2026Article
- Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs.bioRxiv : the preprint server for biology · 2026Article
- A Road Map to Understanding Cardiovascular Disease in Diabetes: From the AHA Strategically Focused Research Network in Cardiometabolic Health and Type 2 Diabetes.Circulation research · 2026Review
- Single-cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1Nature cardiovascular research · 2025Article
- Lactate-Activated GPR132-Src Signal Induces Macrophage Senescence and Aggravates Atherosclerosis Under Diabetes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- High-Content Microscopy Drug Screening Platform for Regulators of the Extracellular Digestion of Lipoprotein Aggregates by Macrophages.ACS pharmacology & translational science · 2025Article
- Applications of Artificial Intelligence in Drug Repurposing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Carnitine O-Acetyltransferase as a Central Player in Lipid and Branched-Chain Amino Acid Metabolism, Epigenetics, Cell Plasticity, and Organelle Function.Biomolecules · 2025Review
- Adiponectin and Adiponectin Receptors in Atherosclerosis.Endocrine reviews · 2025Review
- Drug repositioning pipeline integrating community analysis in drug-drug similarity networks and automated ATC community labeling to foster molecular docking analysis.Frontiers in bioinformatics · 2025Article
- Precision cardiovascular medicine: shifting the innovation paradigm.Frontiers in science · 2025Article
- Decoding Macrophage Heterogeneity to Unravel Vascular Inflammation as a Path to Precision Medicine.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Resolving neutrophils through genetic deletion of TRAM attenuate atherosclerosis pathogenesis.iScience · 2024Article
- Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.Pharmacological research · 2024Article
- The IRG1-itaconate axis protects from cholesterol-induced inflammation and atherosclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Immunologic Aspects in Fibrodysplasia Ossificans Progressiva.Biomolecules · 2024Review
- Gene expression profiles of precursor cells identify compounds that reduce NRP1 surface expression in macrophages: Implication for drug repositioning for COVID-19.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
25 authors at 2 institutions in 1 country.
Letizia AmadoriDepartment of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, New York, NY, USA.
Claudia CalcagnoBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dawn M FernandezDepartment of Medicine, Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Simon KoplevMount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Nicolas FernandezMount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ravneet KaurDepartment of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, New York, NY, USA.
Pauline MuryDepartment of Medicine, Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Nayaab S KhanDepartment of Medicine, Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Swathy SajjaDepartment of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, New York, NY, USA.
Roza ShamailovaDepartment of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, New York, NY, USA.
Yannick CyrDepartment of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, New York, NY, USA.
Minji JeonMount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Christopher A HillDepartment of Medicine, Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Peik Sean ChongThe Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sonum NaiduBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ken SakuraiBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Adam Ali GhotbiBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Raphael SolerBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Natalia EberhardtDepartment of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, New York, NY, USA.
Adeeb RahmanThe Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Peter FariesDepartment of Surgery, Vascular Division, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kathryn J MooreDepartment of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, New York, NY, USA.
Zahi A FayadBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Avi Ma'ayanMount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Chiara GiannarelliDepartment of Medicine, Division of Cardiology, NYU Cardiovascular Research Center, New York, NY, USA.
Icahn School of Medicine at Mount Sinai · USNYU Langone Health · US
Funding
Resolving Macrophage Inflammation in Atherosclerotic Plaques and Other Sites in Insulin ResistanceP01HL131481 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANN MARIE SCHMIDT · 2017 to 2026
$27.3MData Coordination and Integration Center for LINCS-BD2KU54HL127624 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MA'AYAN, AVI, SCHURER, STEPHAN C · 2014 to 2019
$23.5MTRAINING PROGRAM IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007824 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GELB, BRUCE D · 1995 to 2022
$8.6MNon-coding RNA regulation of cholesterol homeostasis and atherosclerosisR35HL135799 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MOORE, KATHRYN J · 2017 to 2023
$6.7MElucidating the Molecular Mechanisms that Mediate DKD Progression in Patients Living with HIVR01DK131525 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI John Cijiang He, Avi Ma'ayan · 2022 to 2026
$4.2MThe LINCS DCIC Engagement Plan with the CFDEOT2OD030160 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MA'AYAN, AVI · 2020 to 2024
$3.4MStudying Atherosclerosis Macrophage Dynamics by Combined PET and Fluorine-MRIR01HL143814 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2019 to 2022
$3.4MDissecting the role of CD8+ T cells in atherosclerosisR01HL153712 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GIANNARELLI, CHIARA · 2020 to 2024
$3.3MDiabetes Data and Hypothesis Hub (D2H2)RC2DK131995 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ATTIE, ALAN D, MA'AYAN, AVI · 2022 to 2023
$2.1MNetwork-driven drug repurposing approaches to treat coronary artery diseaseR21TR001739 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BJORKEGREN, JOHAN M, GIANNARELLI, CHIARA · 2016 to 2017
$678kSingle-cell-driven drug repositioning approaches to target inflammation in atherosclerosisUH2TR002067 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GIANNARELLI, CHIARA · 2017 to 2018
$678kSingle-cell-driven drug repositioning approaches to target inflammation in atherosclerosisUH3TR002067 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GIANNARELLI, CHIARA · 2019 to 2019
$170kAmerican Heart Association-American Stroke Association 965509NCATS NIH HHS R21 TR001739NCATS NIH HHS UH2 TR002067NCATS NIH HHS UH3 TR002067NHLBI NIH HHS P01 HL131481NHLBI NIH HHS R01 HL143814NHLBI NIH HHS R01 HL153712NHLBI NIH HHS R35 HL135799NHLBI NIH HHS T32 HL007824NHLBI NIH HHS U54 HL127624NIDDK NIH HHS R01 DK131525NIDDK NIH HHS RC2 DK131995NIH HHS OT2 OD030160
Abstract
The development of new immunotherapies to treat the inflammatory mechanisms that sustain atherosclerotic cardiovascular disease (ASCVD) is urgently needed. Herein, we present a path to drug repurposing to identify immunotherapies for ASCVD. The integration of time-of-flight mass cytometry and RNA sequencing identified unique inflammatory signatures in peripheral blood mononuclear cells stimulated with ASCVD plasma. By comparing these inflammatory signatures to large-scale gene expression data from the LINCS L1000 dataset, we identified drugs that could reverse this inflammatory response. Ex vivo screens, using human samples, showed that saracatinib-a phase 2a-ready SRC and ABL inhibitor-reversed the inflammatory responses induced by ASCVD plasma. In Apoe
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.