Evidence map›Paper›PMID 37771507›Full record

ReviewJournal of nutritional science2023

Are epigenetic mechanisms and nutrition effective in male and female infertility?

Kadriye Erdoğan, Nazlı Tunca Sanlier, Nevin Sanlier

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nutritional science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kadriye ErdoğanDepartment of Obstetrics and Gynecology, Health Sciences University, Etlik Zübeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey.
Nazlı Tunca SanlierDepartment of Obstetrics and Gynecology, Ankara City Hospital, Ankara, Turkey.
Nevin SanlierDepartment of Nutrition and Dietetics, School of Health Sciences, Ankara Medipol University, Altındağ, Ankara 06050, Turkey.
Memorial Ankara Hospital · TRZübeyde Hanim Maternity Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review discusses epigenetic mechanisms and the relationship of infertility in men and women in relation to parameters pertaining to nutrition. The prevalence of infertility worldwide is 8-12 %, and one out of every eight couples receives medical treatment. Epigenetic mechanisms, aging, environmental factors, dietary energy and nutrients and non-nutrient compounds; more or less energy intake, and methionine come into play in the occurrence of infertility. It also interacts with vitamins B12, D and B6, biotin, choline, selenium, zinc, folic acid, resveratrol, quercetin and similar factors. To understand the molecular mechanisms regulating the expression of genes that affect infertility, the environment, the role of genotype, age, health, nutrition and changes in the individual's epigenotype must first be considered. This will pave the way for the identification of the unknown causes of infertility. Insufficient or excessive intake of energy and certain macro and micronutrients may contribute to the occurrence of infertility as well. In addition, it is reported that 5-10 % of body weight loss, moderate physical activity and nutritional interventions for improvement in insulin sensitivity contribute to the development of fertility. Processes that pertain to epigenetics carry alterations which are inherited yet not encoded via the DNA sequence. Nutrition is believed to have an impact over the epigenetic mechanisms which are effective in the pathogenesis of several diseases like infertility. Epigenetic mechanisms of individuals with infertility are different from healthy individuals. Infertility is associated with epigenetic mechanisms, nutrients, bioactive components and numerous other factors.

Indexed as

Infertility, FemaleEpigenesis, GeneticFemaleGenotypeHumansMale5mc, 5-methylcytosineAgingAMH, anti-Müllerian hormoneART, assisted reproductive techniqueCoQ10, coenzyme Q10CpG dinucleotides, context of guanineDMR, distinct methylated regionDNMT, DNA methyltransferaseEpigeneticFemaleFSH, follicle stimulating hormoneH2A, H2B, H3 and H4, nucleosomal core histonesHOXA10, HomeoboxA10HPR, histone-protamine ratioICMART, International Committee for Monitoring Assisted Reproductive TechnologiesICR, imprinted control regionICSI, intracytoplasmic sperm injectionIL-6, interleukin-6InfertilityIVF, in vitro fertilisationlncRNA, long non-coding RNAMaleMAR, matrix attachment regionmiRNA, micro-RNAmRNA, coding RNAMTHFR, methylenetetrahydrofolate reductasencRNA, non-coding RNANIFT, non-IVF fertility treatmentNTD, neural tube defectNutritionOAT, oligo-astheno-teratozoospermiaP1, P2, potamine 1, potamine 2PCOS, polycystic ovary syndromepiRNA, piwi-interacting RNAROS, reactive oxygen speciesSAM, S-adenosylmethionineSHBG, sex hormone-binding globulinsiRNA, small interfering RNASNP, single nucleotide polymorphismSNRPN, small nuclear ribonucleoprotein polypeptide NTP1, TP2, transition proteinsUMI, unexplained male infertilityVDR, vitamin D receptor

Identifiers

PMID37771507
PMCPMC10523291
OpenAlexW4387056462

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.