Evidence map›Paper›PMID 37772681›Full record

ArticlePediatric pulmonology2024

Metformin use is associated with decreased asthma exacerbations in adolescents and young adults.

Erhan Ararat, Reid D Landes, Erick Forno, Emir Tas, Tamara T Perry

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric pulmonology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Targeting mitochondrial function as a potential therapeutic approach for allergic asthma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Erhan AraratDepartment of Pediatrics, Division of Pulmonology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0003-1880-4827
Reid D LandesDepartment of Biostatistics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Erick FornoDivision of Pediatric Pulmonary, Allergy, and Sleep Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0001-6497-9885
Emir TasDivision of Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Tamara T PerryDepartment of Pediatrics, Allergy and Immunology, University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, Arkansas, USA.
University of Arkansas for Medical Sciences · USArkansas Children's Hospital · USChildren's Hospital of Pittsburgh · USIndiana University School of Medicine

Funding

The Role of the Mitochondrion in the Metabolic Stress Response to Burn TraumaP20GM109096 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI BORSHEIM, ELISABET · 2016 to 2025
$20.7M
NIGMS NIH HHS P20 GM109096
6 · The paper itself

Abstract

rationaleMetformin is a commonly used antidiabetes medication with suggested anti-inflammatory and antioxidative effects. Metformin use has been associated with lower risk of asthma exacerbations and hospitalizations in adults. Here, we aimed to evaluate how asthma exacerbation rates changed after adolescents and young adults were prescribed metformin, and to learn if those changes were related to metformin prescription adherence.

methodsUsing secondary data of patients between 12 and 20 years old with asthma diagnosis and a metformin prescription from the Arkansas All Payers Claim Database and Arkansas School body mass index (BMI) database, we estimated the change in annualized asthma exacerbation rates after metformin prescription. We also evaluated the association of prescription adherence to the changes in those rates using univariate and multivariate regression models.

resultsA total of 464 patients met inclusion criteria. Outpatient exacerbation rates decreased after metformin prescription (13.4% only before vs. 7.8% only after, p = .009), and the annualized rate decreased more after metformin prescription as adherence increased (rank r = -.165, p < .001). After adjusting for potential confounders-age, sex, BMI, and inhaled corticoid steroid use-the strength of the association was attenuated.

conclusionsAsthma exacerbation rates decreased after metformin prescription, but a larger sample of patients who have experienced exacerbations and including patients with asthma who have not been prescribed metformin is needed to better know whether these decreases are driven by metformin use.

Indexed as

Anti-Asthmatic AgentsAsthmaMetforminAdolescentAdrenal Cortex HormonesAdultChildDisease ProgressionHumansYoung AdultAdrenal Cortex HormonesAnti-Asthmatic AgentsMetformindiabetesobesity

Identifiers

PMID37772681
PMCPMC10872793
OpenAlexW4387157172

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.