Evidence map›Paper›PMID 37772844›Full record

ArticleParasite (Paris, France)2023

Morphological atypia and molecular profile of Plasmodium vivax: Findings from an outbreak in the Brazilian Amazon.

Amanda Caroline de Jesus Alves, Ana Cecília Feio Dos Santos, José Mário Veloso Peres, José Maria de Souza Nascimento, Danielle Regina Lima Barbosa, Juliana Vasconcelos Figueiredo, Giselle Maria Rachid Viana, Marinete Marins Póvoa

Abstract read
In one paragraph

Article in Parasite (Paris, France), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amanda Caroline de Jesus AlvesGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Rua Augusto Corrêa, 01, Belém, Pará, Brazil - Laboratory of Malaria Entomology, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil.ORCID 0000-0002-3239-6949
Ana Cecília Feio Dos SantosGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Rua Augusto Corrêa, 01, Belém, Pará, Brazil - Laboratory of Malaria Entomology, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil.ORCID 0000-0001-8884-8863
José Mário Veloso PeresLaboratory of Basic Research in Malaria, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil.
José Maria de Souza NascimentoLaboratory of Basic Research in Malaria, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil.
Danielle Regina Lima BarbosaLaboratory of Malaria Entomology, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil.ORCID 0000-0001-5054-2033
Juliana Vasconcelos FigueiredoMultiprofessional Residency Program in Animal Reproduction, Federal Rural University of the Amazon, Avenida Presidente Tancredo Neves, 2501, Belém, Pará, Brazil.
Giselle Maria Rachid VianaGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Rua Augusto Corrêa, 01, Belém, Pará, Brazil - Laboratory of Basic Research in Malaria, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil.ORCID 0000-0003-1771-7211
Marinete Marins PóvoaGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Rua Augusto Corrêa, 01, Belém, Pará, Brazil - Laboratory of Malaria Entomology, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 302292/2017-2019Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
6 · The paper itself

Abstract

This study aimed to perform morphological and molecular analyses of parasites isolated from the blood of malaria-infected individuals during an outbreak in the Microregion of Cametá, State of Pará, Brazilian Amazon. A total of 260 positive samples were identified by microscopy as Plasmodium vivax; however, in three samples, forms considered unusual for the species were found and defined as morphological atypia of P. vivax. Single P. vivax infection was confirmed by qPCR in all samples. Among 256 genotyped samples, the VK247 genotype alone was identified in 255 samples, and the VK210 genotype was found in only one. The study showed that this malaria outbreak was caused by the etiological agent P. vivax, and for the first time, morphological atypia was described in isolates circulating in Brazil. Likewise, for the first time, the VK247 genotype was detected predominantly in single infections in an area of the State of Pará, which may suggest a greater circulation of the genotype in the region.

Indexed as

MalariaMalaria, VivaxBrazilHumansPlasmodium vivaxProtozoan ProteinsProtozoan ProteinsGenotypingMorphological atypiaOutbreakPlasmodium vivax

Identifiers

PMID37772844
PMCPMC10540677

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.