Evidence map›Paper›PMID 37776222›Full record

ArticleJournal of the American Heart Association2023

Complex Percutaneous Coronary Intervention Outcomes in Older Adults.

Jonathan M Hanna, Stephen Y Wang, Ajar Kochar, Dae Yong Park, Abdulla A Damluji, Glen A Henry, Yousif Ahmad, Jeptha P Curtis, Michael G Nanna

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  8. Article
  9. Review
  10. Validation of complex PCI criteria in drug-coated balloon angioplasty.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Observational
  11. Article
  12. Article
  13. Contemporary Saphenous Vein Graft Intervention: New Insights but Still More Questions.Journal of the Society for Cardiovascular Angiography & Interventions · 2024
    Article
  14. Review
  15. Review
  16. Article
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  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jonathan M HannaDepartment of Internal Medicine Yale School of Medicine New Haven CT USA.
Stephen Y WangDepartment of Internal Medicine Yale School of Medicine New Haven CT USA.ORCID 0000-0001-5176-5618
Ajar KocharDepartment of Cardiovascular Medicine Brigham and Women's Hospital, Harvard Medical School Boston MA USA.ORCID 0000-0003-3570-2136
Dae Yong ParkDepartment of Medicine, Cook County Health Chicago IL USA.ORCID 0000-0002-1486-7452
Abdulla A DamlujiInova Center of Outcomes Research Falls Church VA USA.ORCID 0000-0002-8774-6416
Glen A HenrySection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine New Haven CT USA.
Yousif AhmadSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine New Haven CT USA.ORCID 0000-0002-1364-8055
Jeptha P CurtisSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine New Haven CT USA.ORCID 0000-0002-6872-0501
Michael G NannaSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine New Haven CT USA.ORCID 0000-0001-5745-1636
Yale University · USBrigham and Women's Hospital · USCook County Health and Hospitals System · USInova Health System · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
Frailty and Resiliency in Older Adults with Acute Myocardial InfarctionK23HL153771 · NHLBI · INOVA HEALTH CARE SERVICES · PI DAMLUJI, ABDULLA AL · 2020 to 2024
$916k
Generating novel predictive models to estimate the risk of future ASCVD & Dementia in older adultsR03AG074067 · NIA · YALE UNIVERSITY · PI NANNA, MICHAEL · 2021 to 2022
$335k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K23 HL153771NIA NIH HHS P30 AG021334NIA NIH HHS R03 AG074067
6 · The paper itself

Abstract

Background Complex percutaneous coronary intervention (PCI) is increasingly performed in older adults (age ≥75 years) with stable ischemic heart disease. However, little is known about clinical outcomes. Methods and Results We derived a cohort of older adults undergoing elective PCI for stable ischemic heart disease across a large health system. We compared 12-month event-free survival (freedom from all-cause death, nonfatal myocardial infarction, stroke, and major bleeding), all-cause death, target lesion revascularization, and bleeding events for patients receiving complex versus noncomplex PCI and derived risk estimates with Cox regression models. We included 513 patients (mean age, 81±5 years). Patients receiving complex PCI versus noncomplex PCI did not significantly differ across a host of clinical characteristics including cardiovascular disease features, noncardiac comorbidities, guideline-directed medical therapy use, and frailty. Patients receiving complex PCI versus noncomplex PCI experienced worse event-free survival (80.4% versus 86.8%), which was not significant in adjusted analyses (hazard ratio [HR], 1.38 [95% CI, 0.88-2.16]). All-cause death at 1 year for patients undergoing complex PCI was nearly double that seen for patients receiving noncomplex PCI (10.2% versus 5.9%), and the risk was significant in models adjusted for clinical characteristics (HR, 1.97 [95% CI, 1.02-3.79]). Target lesion revascularization risk was lower for patients receiving complex PCI (2.2% versus 3.5%, adjusted HR), but bleeding events were not statistically different between groups (25.3% versus 20.5%;

Indexed as

Coronary Artery DiseaseMyocardial InfarctionMyocardial IschemiaPercutaneous Coronary InterventionAgedAged, 80 and overHemorrhageHumansTreatment Outcomecomplex percutaneous coronary interventioncoronary artery diseaseolder adultsrevascularization

Identifiers

PMID37776222
PMCPMC10727245
OpenAlexW4387218320

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.