ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2023
Augmented resting beat-to-beat blood pressure variability in patients with chronic kidney disease.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 11 citations in OpenAlex.
- Acute isometric handgrip exercise enhances cardiac baroreflex sensitivity and lowers systolic blood pressure in chronic kidney disease.Autonomic neuroscience : basic & clinical · 2026Trial
- Sex differences in beat-to-beat blood pressure variability following isometric handgrip exercise.European journal of applied physiology · 2026Trial
- Aerobic Cycling Exercise Training Does Not Improve Impaired Vagal Reactivation in Patients with Chronic Kidney Disease.Medicine and science in sports and exercise · 2025Trial
- Autonomic modulation with mindfulness-based stress reduction in chronic kidney disease: a randomized controlled trial.The Journal of physiology · 2025Trial
- The impact of blood pressure variability and African Caribbean ethnicity on the progression of diabetic kidney disease in type 1 diabetes.Diabetologia · 2026Article
- Individuals with posttraumatic stress disorder have increased beat-to-beat blood pressure variability.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Blood Flow Restriction Training in Hemodialysis Patients: Clinical Benefits, Challenges, and Future Perspectives.Hemodialysis international. International Symposium on Home Hemodialysis · 2026Review
- Interactions between blood pressure variability, cerebral autoregulation, and covert cerebral small vessel disease in relation to cognitive performance in community-dwelling older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Autonomic-vascular dysregulation in CKD-associated hypertension: a narrative review with evidence hierarchy.Frontiers in neuroscience · 2026Review
- Hypoxia disrupts neurovascular regulation of blood pressure in normotensive and untreated hypertensive men.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Blood pressure variability and cerebrovascular risk in maintenance hemodialysis versus peritoneal dialysis: a comparative study.Renal failure · 2025Article
- Vasomotor symptoms of menopause, sympathetic activity, and blood pressure in postmenopausal females.American journal of physiology. Heart and circulatory physiology · 2025Article
- Resting beat-to-beat blood pressure variability in humans: role of alpha-1 adrenergic receptors.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Impaired Neurocirculatory Control in Chronic Kidney Disease: New Evidence for Blunted Sympathetic Baroreflex and Reduced Sympathetic Transduction.Function (Oxford, England) · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeOur aim was to test the hypothesis that patients with chronic kidney disease (CKD) would exhibit augmented resting beat-to-beat blood pressure variability (BPV) that is associated with poor clinical outcomes independent of mean blood pressure (BP). In addition, since the arterial baroreflex plays a critical role in beat-to-beat BP regulation, we further hypothesized that an impaired baroreflex control would be associated with an augmented resting beat-to-beat BPV.
methodsIn 25 sedentary patients with CKD stages III-IV (62 ± 9 years) and 20 controls (57 ± 10 years), resting beat-to-beat BP (finger photoplethysmography) and heart rate (electrocardiography) were continuously measured for 10 min. We calculated the standard deviation (SD), average real variability (ARV) and other indices of BPV. The sequence technique was used to estimate spontaneous cardiac baroreflex sensitivity.
resultsCompared with controls (CON), the CKD group had significantly increased resting BPV. The ARV (2.2 ± 0.6 versus 1.6 ± 0.5 mmHg, P < 0.001; 1.6 ± 0.7 versus 1.3 ± 0.3 mmHg, P = 0.039; 1.4 ± 0.5 versus 1.0 ± 0.2 mmHg, P < 0.001) of systolic, diastolic and mean BP, respectively, was increased in CKD versus controls. Other traditional measures of variability showed similar results. The cardiac baroreflex sensitivity was lower in CKD compared with controls (CKD: 8.4 ± 4.5 ms/mmHg versus CON: 14.0 ± 8.2 ms/mmHg, P = 0.008). In addition, cardiac baroreflex sensitivity was negatively associated with BPV [systolic blood pressure (SBP) ARV; r = -0.44, P = 0.003].
conclusionIn summary, our data demonstrate that patients with CKD have augmented beat-to-beat BPV and lower cardiac baroreflex sensitivity. BPV and cardiac baroreflex sensitivity were negatively correlated in this cohort. These findings may further our understanding about cardiovascular dysregulation observed in patients with CKD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.