Evidence mapPaperPMID 37777014Full record

ArticleJournal of lipid research2023

LDL binding to cell receptors and extracellular matrix is proatherogenic in obesity but improves after bariatric surgery.

Shobini Jayaraman, Antonio Pérez, Inka Miñambres, Jose Luis Sánchez-Quesada, Olga Gursky

Open access · goldAbstract read
In one paragraph

Article in Journal of lipid research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Review
  4. Review
  5. Article
  6. Observational
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Shobini JayaramanDepartment of Pharmacology, Physiology & Biophysics, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, USA. Electronic address: shobini@bu.edu.
Antonio PérezEndocrinology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; CIBER of Diabetes and Metabolic Diseases (CIBERDEM), Barcelona, Spain.
Inka MiñambresEndocrinology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Jose Luis Sánchez-QuesadaCIBER of Diabetes and Metabolic Diseases (CIBERDEM), Barcelona, Spain; Cardiovascular Biochemistry Group, Research Institute of the Hospital de Sant Pau, CIBERDEM, Barcelona, Spain. Electronic address: JSanchezQ@santpau.cat.
Olga GurskyDepartment of Pharmacology, Physiology & Biophysics, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, USA.
Hospital de Sant Pau · ESBoston University · US

Funding

Structure and Function of Serum Amyloid A in Health and DiseaseR01GM135158 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · 2022 to 2025
$929k
Structural Thermodynamics of Human Apolipoprotein C-1R01GM067260 · BOSTON UNIVERSITY MEDICAL CAMPUS · 2003 to 2005
$849k
NIGMS NIH HHS R01 GM067260NIGMS NIH HHS R01 GM135158
6 · The paper itself

Abstract

Obesity is a major global public health issue involving dyslipidemia, oxidative stress, inflammation, and increased risk of CVD. Weight loss reduces this risk, but the biochemical underpinnings are unclear. We explored how obesity and weight loss after bariatric surgery influence LDL interactions that trigger proatherogenic versus antiatherogenic processes. LDL was isolated from plasma of six patients with severe obesity before (basal) and 6-12 months after bariatric surgery (basal BMI = 42.7 kg/m

Indexed as

Bariatric SurgeryCardiovascular DiseasesExtracellular MatrixHumansInflammationLipoproteins, LDLObesityReceptors, LDLWeight LossLipoproteins, LDLReceptors, LDLCD36 and LOX-1Inflammation in obesityLDL binding to LDL receptorLDL retention by matrix proteins and glycosaminoglycansLipoprotein lipolysisoxidation and aggregation

Identifiers

PMID37777014
PMCPMC10665669
OpenAlexW4387125628

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.