Evidence map›Paper›PMID 37777158›Full record

ArticleThe Journal of biological chemistry2023

Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2-ERK depending on downregulation of proteasome-related genes.

Xinzhi Li, Chunhong Liu, Zhimin Zhang, Xueying Li, Zhicheng Yao, Yanbin Dong, Xin Wang, Zheng Chen

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Targeting RNA adenosine editing and modification enzymes for RNA therapeutics.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  3. YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xinzhi LiHIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Chunhong LiuHIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Zhimin ZhangHIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Xueying LiHIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Zhicheng YaoDepartment of General surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yanbin DongInstitute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Xin WangHIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Zheng ChenHIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China. Electronic address: chenzheng@hit.edu.cn.
Harbin Institute of Technology · CNChinese Academy of Sciences · CNThird Affiliated Hospital of Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wilm's tumor 1-associating protein (WTAP), a regulatory protein of the m

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAnimalsCell Cycle ProteinsCell ProliferationDown-RegulationExtracellular Signal-Regulated MAP KinasesGRB2 Adaptor ProteinHepatocytesMiceMice, Inbred C57BLMice, KnockoutProteasome Endopeptidase ComplexRNA Splicing FactorsCell Cycle ProteinsExtracellular Signal-Regulated MAP KinasesGRB2 Adaptor ProteinGrb2 protein, mouseProteasome Endopeptidase ComplexRNA Splicing FactorsWtap protein, mouseERKGRB2HCCinflammationproteasomeWTAP

Identifiers

PMID37777158
PMCPMC10630636
OpenAlexW4387142850

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.