Evidence map›Paper›PMID 37777359›Full record

ArticleSleep health2024

Distribution of dim light melatonin offset (DLMOff) and phase relationship to waketime in healthy adults and associations with chronotype.

Rebecca C Cox, Alivia B Blumenstein, Tina M Burke, Christopher M Depner, Molly K Guerin, Emily Hay-Arthur, Janine Higgins, Oliver A Knauer, Shannon M Lanza, Rachel R Markwald and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Rebecca C CoxSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Alivia B BlumensteinSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Tina M BurkeSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA; Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Christopher M DepnerSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA; Department of Health and Kinesiology, University of Utah, Salt Lake City, Utah, USA.
Molly K GuerinSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Emily Hay-ArthurSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Janine HigginsDivision of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Oliver A KnauerSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Shannon M LanzaSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Rachel R MarkwaldSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA; Naval Health Research Center, San Diego, California, USA.
Edward L MelansonDivision of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA; Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Andrew W McHillSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA; Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, Oregon, USA.
Sarah J MortonSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Hannah K RitchieSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Mark R SmithSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Alexandra N SmitsSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Kate E SprecherSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Ellen R StothardSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA; Colorado Sleep Institute, Boulder, Colorado, USA.
Dana WithrowSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Kenneth P WrightSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA; Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address: Kenneth.Wright@Colorado.edu.
University of Colorado Boulder · USUniversity of Colorado Anschutz Medical Campus · USOregon Health & Science University · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5M
Oregon Clinical and Translational Research Institute KL2 SupplementKL2TR002370 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Catherine Lee Hough · 2017 to 2026
$10.1M
Biomarkers for Peripheral Circadian Clocks in HumansR01HL165343 · NHLBI · UNIVERSITY OF COLORADO · PI Kenneth P Wright · 2023 to 2026
$2.7M
Metabolic and Cognitive Consequences of Sleep LossR01HL109706 · NHLBI · UNIVERSITY OF COLORADO · PI WRIGHT, KENNETH P · 2011 to 2014
$2.3M
Transdisciplinary Training in Sleep and Circadian RhythmsT32HL149646 · NHLBI · UNIVERSITY OF COLORADO · PI Kenneth P Wright · 2020 to 2026
$1.6M
Biomarkers of Insufficient Sleep and SleepinessR01HL132150 · NHLBI · UNIVERSITY OF COLORADO · PI REISDORPH, NICHOLE A, WRIGHT, KENNETH P · 2016 to 2017
$1.2M
Biomarkers and Altered Metabolic Pathways during Sleep Loss and Circadian DisruptionK01HL145099 · NHLBI · UNIVERSITY OF UTAH · PI DEPNER, CHRISTOPHER MICHAEL · 2019 to 2023
$888k
NCATS NIH HHS KL2 TR002370NCATS NIH HHS UL1 TR000154NCATS NIH HHS UL1 TR001082NCATS NIH HHS UL1 TR002535NCRR NIH HHS UL1 RR025780NHLBI NIH HHS K01 HL145099NHLBI NIH HHS R01 HL109706NHLBI NIH HHS R01 HL132150NHLBI NIH HHS R01 HL165343NHLBI NIH HHS R56 HL165343NHLBI NIH HHS T32 HL007901NHLBI NIH HHS T32 HL149646NIDDK NIH HHS F32 DK107146NIDDK NIH HHS F32 DK111161NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R21 DK092624
6 · The paper itself

Abstract

objectivesDim light melatonin onset, or the rise in melatonin levels representing the beginning of the biological night, is the gold standard indicator of circadian phase. Considerably less is known about dim light melatonin offset, or the decrease in melatonin to low daytime levels representing the end of the biological night. In the context of insufficient sleep, morning circadian misalignment, or energy intake after waketime but before dim light melatonin offset, is linked to impaired insulin sensitivity, suggesting the need to characterize dim light melatonin offset and identify risk for morning circadian misalignment.

methodsWe examined the distributions of dim light melatonin offset clock hour and the phase relationship between dim light melatonin offset and waketime, and associations between dim light melatonin offset, phase relationship, and chronotype in healthy adults (N = 62) who completed baseline protocols measuring components of the circadian melatonin rhythm and chronotype.

results74.4% demonstrated dim light melatonin offset after waketime, indicating most healthy adults wake up before the end of biological night. Later chronotype (morningness-eveningness, mid-sleep on free days corrected, and average mid-sleep) was associated with later dim light melatonin offset clock hour. Later chronotype was also associated with a larger, positive phase relationship between dim light melatonin offset and waketime, except for morningness-eveningness.

conclusionsThese findings suggest morning circadian misalignment risk among healthy adults, which would not be detected if only dim light melatonin onset were assessed. Chronotype measured by sleep timing may better predict this risk in healthy adults keeping a consistent sleep schedule than morningness-eveningness preferences. Additional research is needed to develop circadian biomarkers to predict dim light melatonin offset and evaluate appropriate dim light melatonin offset timing to promote health.

Indexed as

MelatoninAdultChronotypeCircadian RhythmHealth PromotionHumansSleepSurveys and QuestionnairesMelatoninChronotypeCircadian misalignmentDim light melatonin offsetDim light melatonin onsetMelatonin durationPhase angle of entrainment

Identifiers

PMID37777359
PMCPMC12693690
OpenAlexW4387142432

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.