Evidence map›Paper›PMID 37778398›Full record

ReviewVeterinary and comparative oncology2023

Leading the pack: Best practices in comparative canine cancer genomics to inform human oncology.

Cheryl A London, Heather Gardner, Shaying Zhao, Deborah W Knapp, Sagar M Utturkar, Dawn L Duval, Melissa R Chambers, Elaine Ostrander, Jeffrey M Trent, Gina Kuffel

Abstract readReview
In one paragraph

Review in Veterinary and comparative oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Beyond Rodents: Alternative Animal Models in Colorectal Cancer Research.International journal of molecular sciences · 2025
    Review
  5. Review
  6. From Genetics to Function: the Role of ABCA12 in Autism Neurobiology.Journal of molecular neuroscience : MN · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. [Comparative pathology in oncology-Best practice].Pathologie (Heidelberg, Germany) · 2024
    Review
  12. Exploring the One Health Paradigm in Male Breast Cancer.Journal of mammary gland biology and neoplasia · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cheryl A LondonCummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.ORCID https://orcid.org/0000-0001-8563-1490
Heather GardnerCummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.ORCID https://orcid.org/0000-0001-6007-6144
Shaying ZhaoUniversity of Georgia Cancer Center, University of Georgia, Athens, Georgia, USA.ORCID https://orcid.org/0000-0001-5852-9570
Deborah W KnappCollege of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0000-0002-0059-0202
Sagar M UtturkarPurdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0000-0002-3453-1948
Dawn L DuvalCollege of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.ORCID https://orcid.org/0000-0002-5310-0078
Melissa R ChambersSchool of Medicine, University of Alabama, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0001-8989-7018
Elaine OstranderCancer Genetics and Comparative Genomics Branch, National Cancer Institute, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0001-6075-9738
Jeffrey M TrentTranslational Genomics Research Institute, Phoenix, Arizona, USA.ORCID https://orcid.org/0000-0003-0183-4202
Gina KuffelNational Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0003-4061-0092

Funding

Enhancing the efficacy of immunotherapy in DLBCL using rational combination approachesU01CA224153 · NCI · TUFTS UNIVERSITY BOSTON · PI LONDON, CHERYL A · 2017 to 2021
$3.1M
Optimizing Novel Immunotherapy Combinations Targeting the Tumor Microenvironment in Canine Spontaneous OsteosarcomaU01CA224182 · NCI · COLORADO STATE UNIVERSITY · PI DOW, STEVEN W., LONDON, CHERYL A · 2017 to 2022
$2.8M
rPIV5- and AVLP-vectored vaccine development with public tumor-specific neoantigensR01CA252713 · NCI · UNIVERSITY OF GEORGIA · PI HILDEBRAND, WILLIAM, ZHAO, SHAYING · 2021 to 2025
$2.6M
Man's Best Friend for Driver-Passenger DistinctionR01CA182093 · NCI · UNIVERSITY OF GEORGIA · PI ZHAO, SHAYING · 2014 to 2018
$1.6M
Elucidating the therapeutic utility of targeting metabolic dependencies in osteosarcomaK01OD028268 · OD · TUFTS UNIVERSITY BOSTON · PI GARDNER, HEATHER LYNN · 2020 to 2024
$631k
NCI NIH HHS R01 CA182093NCI NIH HHS R01 CA252713NCI NIH HHS U01 CA224153NCI NIH HHS U01 CA224182NIH HHS K01 OD028268
6 · The paper itself

Abstract

Pet dogs develop spontaneous cancers at a rate estimated to be five times higher than that of humans, providing a unique opportunity to study disease biology and evaluate novel therapeutic strategies in a model system that possesses an intact immune system and mirrors key aspects of human cancer biology. Despite decades of interest, effective utilization of pet dog cancers has been hindered by a limited repertoire of necessary cellular and molecular reagents for both in vitro and in vivo studies, as well as a dearth of information regarding the genomic landscape of these cancers. Recently, many of these critical gaps have been addressed through the generation of a highly annotated canine reference genome, the creation of several tools necessary for multi-omic analysis of canine tumours, and the development of a centralized repository for key genomic and associated clinical information from canine cancer patients, the Integrated Canine Data Commons. Together, these advances have catalysed multidisciplinary efforts designed to integrate the study of pet dog cancers more effectively into the translational continuum, with the ultimate goal of improving human outcomes. The current review summarizes this recent progress and provides a guide to resources and tools available for comparative study of pet dog cancers.

Indexed as

Dog DiseasesNeoplasmsAnimalsDisease Models, AnimalDogsGenomicsHumansMedical Oncologycanine genomedata analysistumour genomics

Identifiers

PMID37778398
PMCPMC12065084

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.