Evidence map›Paper›PMID 37779868›Full record

ReviewJournal of Cancer2023

The Dual Effects of Exosomes on Glioma: A Comprehensive Review.

Maowen Luo, Xingzhao Luan, Gen Jiang, Luxia Yang, Kekun Yan, Shenjie Li, Wei Xiang, Jie Zhou

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Exosomes: a promising avenue for cancer diagnosis beyond treatment.Frontiers in cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Maowen LuoSouthwest Medical University, Luzhou 646000, China.
Xingzhao LuanDepartment of Neurosurgery, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Gen JiangDepartment of Neurosurgery, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Luxia YangDepartment of Neurosurgery, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Kekun YanDepartment of Neurosurgery, the Affiliated Hospital of PanZhiHua University, PanZhiHua 617000, China.
Shenjie LiDepartment of Neurosurgery, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Wei XiangDepartment of Neurosurgery, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Jie ZhouDepartment of Neurosurgery, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Affiliated Hospital of Southwest Medical University · CNFirst Affiliated Hospital of Sichuan Medical University · CNPanzhihua University · CNSouthwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma is a frequently occurring type of cancer that affects the central nervous system. Despite the availability of standardized treatment options including surgical resection, concurrent radiotherapy, and adjuvant temozolomide (TMZ) therapy, the prognosis for glioma patients is often unfavorable. Exosomes act as vehicles for intercellular communication, contributing to tissue repair, immune modulation, and the transfer of metabolic cargo to recipient cells. However, the transmission of abnormal substances can also contribute to pathologic states such as cancer, metabolic diseases, and neurodegenerative disorders. The field of exosome research in oncology has seen significant advancements, with exosomes identified as dynamic modulators of tumor cell proliferation, migration, and invasion, as well as angiogenesis and drug resistance. Exosomes have negligible cytotoxicity, low immunogenicity, and small size, rendering them an ideal therapeutic candidate for glioma. This comprehensive review discusses the dual effects of exosomes in glioma, with an emphasis on their role in facilitating drug resistance. Furthermore, the clinical applications and current limitations of exosomes in glioma therapy are also discussed in detail.

Indexed as

diagnosisdrug resistance.exosomeGliomatherapy

Identifiers

PMID37779868
PMCPMC10539397
OpenAlexW4387098520

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.