ArticleFrontiers in public health2023
Brief research report pesticide occupational exposure leads to significant inflammatory changes in normal mammary breast tissue.
Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Artificial intelligence improves risk stratification for breast cancer recurrence and mortality in women exposed to pesticides: a call for reassessment of stratification criteria.Frontiers in oncology · 2026Article
- Article
- Effect of pesticides on breast cancer tumor.Biology direct · 2025Review
- Pesticide exposome reveals oxidative stress and immune response disruptions in occupationally exposed women with breast cancer.Scientific reports · 2025Article
- Factors associated with recurrence in operable breast cancer patients undergoing surgery as the sole treatment modality.Acta cirurgica brasileira · 2025Article
- Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies have documented the high occurrence of several tumors, including female breast cancer, in populations occupationally exposed to pesticides worldwide. It is believed that in addition to direct DNA damage, other molecular alterations that indicate genomic instability are associated, such as epigenetic modifications and the production of inflammation mediators. The present study characterized the profile of inflammatory changes in the breast tissue of women without cancer occupationally exposed to pesticides. In samples of normal breast tissue collected during biopsy and evaluated as negative for cancer by a pathologist, oxidative stress levels were assessed as inflammatory markers through measurements of lipoperoxides and total antioxidant capacity of the sample (TRAP) by high-sensitivity chemiluminescence, as well as levels of nitric oxide (NOx) metabolites. The levels of inflammation-modulating transcription factors PPAR-
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Registered trials
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