Evidence map›Paper›PMID 37781806›Full record

ArticleJournal of Alzheimer's disease : JAD2023

A Mediterranean Diet and Walking Intervention to Reduce Cognitive Decline and Dementia Risk in Independently Living Older Australians: The MedWalk Randomized Controlled Trial Experimental Protocol, Including COVID-19 Related Modifications and Baseline Characteristics.

Andrew Pipingas, Karen J Murphy, Courtney R Davis, Catherine Itsiopoulos, Michael Kingsley, Andrew Scholey, Helen Macpherson, Leonie Segal, Jeff Breckon, Anne-Marie Minihane and 15 more

Open access · bronzeAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 8 institutions in 3 countries.

Andrew PipingasCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia.
Karen J MurphyAlliance for Research in Exercise, Nutrition and Activity (ARENA), UniSA Allied Health and Human Performance & UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Courtney R DavisAlliance for Research in Exercise, Nutrition and Activity (ARENA), UniSA Allied Health and Human Performance & UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Catherine ItsiopoulosSchool of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.
Michael KingsleyDepartment of Exercise Sciences, The University of Auckland, Newmarket, New Zealand.
Andrew ScholeyCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia.
Helen MacphersonSchool of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition, Deakin University, Burwood, VIC, Australia.
Leonie SegalEconomics and Social Policy Group, Allied Health and Human Performance, University of South Australia, Adelaide, SA, Australia.
Jeff BreckonSchool of Health and Life Sciences, Teesside University, Middlesbrough, UK.
Anne-Marie MinihaneNorwich Medical School, University of East Anglia, Norwich, UK.
Denny MeyerCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia.
Edward OgdenCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia.
Kathryn A DyerAlliance for Research in Exercise, Nutrition and Activity (ARENA), UniSA Allied Health and Human Performance & UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Emily EversteynCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia.
Roy J HardmanCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia.
Kaylass PoorunCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia.
Keri JusticeCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia.
Maher HanaCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia.
Jonathan D BuckleyAlliance for Research in Exercise, Nutrition and Activity (ARENA), UniSA Allied Health and Human Performance & UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
David WhiteCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia.
Kade DavisonAlliance for Research in Exercise, Nutrition and Activity (ARENA), UniSA Allied Health and Human Performance & UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Jessie S ClarkAlliance for Research in Exercise, Nutrition and Activity (ARENA), UniSA Allied Health and Human Performance & UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Ella L BracciAlliance for Research in Exercise, Nutrition and Activity (ARENA), UniSA Allied Health and Human Performance & UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Greg KennedyCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia.
MedWalk collaborative team
Swinburne University of Technology · AUUniversity of South Australia · AUDeakin University · AUMonash University · AURMIT University · AUTeesside University · GBUniversity of Auckland · NZUniversity of East Anglia · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral clinical trials have examined diet and physical activity lifestyle changes as mitigation strategies for risk factors linked to cognitive decline and dementias such as Alzheimer's disease. However, the ability to modify these behaviors longer term, to impact cognitive health has remained elusive.

objectiveThe MedWalk trial's primary aim is to investigate whether longer-term adherence to a Mediterranean-style diet and regular walking, delivered through motivational interviewing and cognitive-behavioral therapy (MI-CBT), can reduce age-associated cognitive decline and other dementia risk factors in older, independently living individuals without cognitive impairment.

methodsMedWalk, a one-year cluster-randomized controlled trial across two Australian states, recruited 60-90-year-old people from independent living retirement villages and the wider community. Participants were assigned to either the MedWalk intervention or a control group (maintaining their usual diet and physical activity). The primary outcome is 12-month change in visual memory and learning assessed from errors on the Paired Associates Learning Task of the Cambridge Neuropsychological Test Automated Battery. Secondary outcomes include cognition, mood, cardiovascular function, biomarkers related to nutrient status and cognitive decline, MI-CBT effectiveness, Mediterranean diet adherence, physical activity, quality of life, cost-effectiveness, and health economic evaluation.Progress and Discussion:Although COVID-19 impacts over two years necessitated a reduced timeline and sample size, MedWalk retains sufficient power to address its aims and hypotheses. Baseline testing has been completed with 157 participants, who will be followed over 12 months. If successful, MedWalk will inform interventions that could substantially reduce dementia incidence and ameliorate cognitive decline in the community.

trial registrationRegistered on the Australia New Zealand Clinical Trials Registry ANZCTR 12620000978965 (https://www.anzctr.org.au).

Indexed as

Cognitive DysfunctionCOVID-19DementiaDiet, MediterraneanAgedAged, 80 and overAustraliaCognitionHumansQuality of LifeRandomized Controlled Trials as TopicWalkingAlzheimer’s diseasecardiovascularcluster-randomized clinical trialcognitioncognitive behavioral therapydementiaexerciseMediterranean dietmoodmotivational interviewingphysical activity

Identifiers

PMID37781806
PMCPMC10657681
OpenAlexW4387188140

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.