Evidence map›Paper›PMID 37782016›Full record

ArticleeLife2023

Regulation of defective mitochondrial DNA accumulation and transmission in

Sagen Flowers, Rushali Kothari, Yamila N Torres Cleuren, Melissa R Alcorn, Chee Kiang Ewe, Geneva Alok, Samantha L Fiallo, Pradeep M Joshi, Joel H Rothman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Mitochondrial curation for the next generation.Current opinion in genetics & development · 2025
    Review
  4. Biomolecules · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Sagen FlowersDepartment of MCD Biology and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United States.ORCID 0000-0002-7818-2188
Rushali KothariDepartment of MCD Biology and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United States.
Yamila N Torres CleurenDepartment of MCD Biology and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United States.
Melissa R AlcornDepartment of MCD Biology and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United States.ORCID 0000-0001-6284-3255
Chee Kiang EweDepartment of MCD Biology and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United States.ORCID 0000-0003-1973-1308
Geneva AlokDepartment of MCD Biology and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United States.
Samantha L FialloDepartment of MCD Biology and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United States.
Pradeep M JoshiDepartment of MCD Biology and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United States.ORCID 0000-0002-4220-0559
Joel H RothmanDepartment of MCD Biology and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, United States.ORCID 0000-0002-6844-1377
University of California, Santa Barbara · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Developmental reprogramming and transorganogenesisR01HD081266 · NICHD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Joel H. Rothman · 2015 to 2026
$3.0M
Plasticity in an embryonic gene regulatory networkR01HD082347 · NICHD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ROTHMAN, JOEL H. · 2015 to 2019
$1.5M
Plasticity in an embryonic gene regulatory networkR01GM143771 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ROTHMAN, JOEL H. · 2021 to 2024
$1.3M
A model for elimination of defective mitochondrial genomesR21AG068915 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ROTHMAN, JOEL H. · 2020 to 2021
$428k
NIA NIH HHS R21 AG068915NICHD NIH HHS R01 HD081266NICHD NIH HHS R01 HD082347NIGMS NIH HHS R01 GM143771NIH HHS P40 OD010440
6 · The paper itself

Abstract

The heteroplasmic state of eukaryotic cells allows for cryptic accumulation of defective mitochondrial genomes (mtDNA). 'Purifying selection' mechanisms operate to remove such dysfunctional mtDNAs. We found that activators of programmed cell death (PCD), including the CED-3 and CSP-1 caspases, the BH3-only protein CED-13, and PCD corpse engulfment factors, are required in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAgingAnimalsApoptosisCaspasesDNA, MitochondrialCaenorhabditis elegans ProteinsCaspasesDNA, MitochondrialagingC. eleganscell biologygeneticsgenomicsheteroplasmyinsulin signalingprogrammed cell deathpurifying selectionuaDf5

Identifiers

PMID37782016
PMCPMC10545429
OpenAlexW4387241382

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.