Evidence map›Paper›PMID 37784015›Full record

ArticleEuropean review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity2023

Change in physical activity and systolic blood pressure trajectories throughout mid-life and the development of dementia in older age: the HUNT study.

Maren Lerfald, Stian Lydersen, Ekaterina Zotcheva, Tom I L Nilsen, Rannveig S Eldholm, Nicolas Martinez-Velilla, Geir Selbæk, Linda Ernstsen

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In one paragraph

Article in European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Maren LerfaldDepartment of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, PO box 8950, N-7491, Trondheim, Norway.
Stian LydersenDepartment of Mental Health, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Trondheim, Norway.
Ekaterina ZotchevaNorwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Oslo, Norway.
Tom I L NilsenDepartment of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, PO box 8950, N-7491, Trondheim, Norway.
Rannveig S EldholmDepartment of Geriatrics, Clinic of Medicine, St.Olavs Hospital, Trondheim, Norway.
Nicolas Martinez-VelillaNavarrabiomed, Hospital Universitario de Navarra, UPNA, IdiSNA, Pamplona, Spain.
Geir SelbækNorwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Oslo, Norway.
Linda ErnstsenDepartment of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, PO box 8950, N-7491, Trondheim, Norway. linda.ernstsen@ntnu.no.
Norwegian University of Science and Technology · NOSt Olav's University Hospital · NONavarrabiomed · ESOslo University Hospital · NOSykehuset i Vestfold · NO

Funding

the Liaison Committee for education, research, and innovation in Central Norway 2022-30545
6 · The paper itself

Abstract

backgroundThere is lack of research on combinations of possible modifiable risk factors for dementia in a life-time perspective. Dementia has currently no cure, and therefore new knowledge of preventive factors is important. The purpose of this study is to investigate if changes in physical activity (PA) in combinations with systolic blood pressure (SBP) trajectories in mid to late life are related to development of dementia in older age.

methodsThis prospective cohort study uses data from four consecutive surveys of the HUNT Study, Norway. Dementia was assessed in the HUNT4 70 + sub-study (2017-19). Group-based trajectory modelling identified three SBP trajectories from HUNT1 (1984-86) to HUNT3 (2006-2008): low, middle, and high. Change in PA was categorized into four groups based on high or low PA level at HUNT1 and HUNT3 and were combined with the SBP trajectories resulting in 12 distinct categories. Logistic regression was used to estimate odds ratios (ORs) of dementia.

resultsA total of 8487 participants (55% women, mean age (SD) 44.8 (6.5) years at HUNT1) were included. At HUNT4 70 + , 15.2% had dementia. We observed an overall decrease in OR of dementia across the PA/SBP categories when ranked from low to high PA (OR, 0.96; 95% CI, 0.93 to 1.00, P = 0.04). Within PA groups, a low SBP trajectory was associated with lower OR for dementia, apart from those with decreasing PA. The strongest association was observed for people with stable high PA and low SBP trajectory (OR, 0.38; 95% confidence interval (CI), 0.13 to 1.10 and adjusted risk difference, -8.34 percentage points; 95% CI, -15.32 to -1.36).

conclusionOur findings illustrate the clinical importance of PA and SBP for dementia prevention and that favorable levels of both are associated with reduced occurrence of dementia.

Indexed as

Blood pressureDementiaPhysical activityTrajectories

Identifiers

PMID37784015
PMCPMC10544393
OpenAlexW4387257178

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.