Evidence map›Paper›PMID 37784136›Full record

ArticleClinical epigenetics2023

Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells.

Javier Perez-Garcia, Maria Pino-Yanes, Elizabeth G Plender, Jamie L Everman, Celeste Eng, Nathan D Jackson, Camille M Moore, Kenneth B Beckman, Vivian Medina, Sunita Sharma and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 4 countries.

Javier Perez-GarciaGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology, and Genetics, Universidad de La Laguna (ULL), La Laguna, Tenerife, Canary Islands, Spain. jpegarci@ull.edu.es.
Maria Pino-YanesGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology, and Genetics, Universidad de La Laguna (ULL), La Laguna, Tenerife, Canary Islands, Spain. mdelpino@ull.edu.es.
Elizabeth G PlenderCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
Jamie L EvermanCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
Celeste EngDepartment of Medicine, University of California San Francisco (UCSF), San Francisco, CA, USA.
Nathan D JacksonCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
Camille M MooreCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
Kenneth B BeckmanUniversity of Minnesota Genomics Center (UMNGC), Minneapolis, MN, USA.
Vivian MedinaCentro de Neumología Pediátrica, San Juan, PR, USA.
Sunita SharmaDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Daniel Efrain WinnicaDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Fernando HolguinDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
José Rodríguez-SantanaCentro de Neumología Pediátrica, San Juan, PR, USA.
Jesús VillarCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Elad ZivInstitute for Human Genetics, University of California San Francisco (UCSF), San Francisco, CA, USA.
Max A Seibold *Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
Esteban G Burchard *Department of Medicine, University of California San Francisco (UCSF), San Francisco, CA, USA.
University of Colorado Denver · USUniversity of California, San Francisco · USCentro de Neumologia Pediatrica · PRUniversidad de La Laguna · ESNational Jewish Health · USSt. Michael's Hospital · CAUniversity of Minnesota · US

Funding

New York Center for Collaborative Research In Common Disease Genomics: Genome Aggregation and Joint Variant Calling for CCDG Freeze2UM1HG008901 · NHGRI · NEW YORK GENOME CENTER · PI MANIATIS, THOMAS P, WIGLER, MICHAEL H · 2016 to 2020
$56.6M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
NHGRI Genome Sequencing Program Coordinating CenterU24HG008956 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, MATISE, TARA C. · 2016 to 2020
$4.9M
Transcriptomic and Pharmacogenetic Asthma Endotypes in Minority ChildrenR01HL135156 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A, ZIV, ELAD · 2017 to 2021
$4.1M
Genes, air pollution, and asthma severity in minority childrenR01MD010443 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEIBOLD, MAX A, ZIV, ELAD · 2016 to 2020
$3.8M
Genetic Control of Airway Epithelium Gene Expression in Childhood AsthmaticsR01HL128439 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2015 to 2019
$3.1M
Epigenomics of asthma risk factors and clinical subtypes in minority childrenR01HL155024 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BORRELL, LUISA N, ZAITLEN, NOAH A · 2021 to 2024
$2.9M
Gene-Environment Analyses of Early Life Exposures and Asthma in Ethnically Diverse ChildrenR21ES024844 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ, GAUDERMAN, WILLIAM JAMES · 2015 to 2017
$509k
Epigenetics of Socio-Environmental Effects on Asthma in MinoritiesR56MD013312 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ, ZAITLEN, NOAH A · 2018 to 2018
$458k
NHGRI NIH HHS U24 HG008956NHGRI NIH HHS UM1 HG008901NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL128439NHLBI NIH HHS R01 HL135156NHLBI NIH HHS R01 HL155024NHLBI NIH HHS R01HL155024-01, HHSN268201600032I, 3R01HL-117626-02S1, HHSN268201800002I, 3R01HL117004-02S3, 3R01HL-120393-02S1, R01HL117004, R01HL128439, R01HL135156, X01HL134589NIEHS NIH HHS HHSN268201600032CNIEHS NIH HHS R01 ES015794NIEHS NIH HHS R01ES015794, R21ES24844NIEHS NIH HHS R21 ES024844NIMHD NIH HHS R01 MD010443NIMHD NIH HHS R01MD010443, R56MD013312NIMHD NIH HHS R56 MD013312
6 · The paper itself

Abstract

backgroundAlbuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and bronchodilator drug response (BDR), no study has assessed whether albuterol could induce changes in the airway epithelial methylome. We aimed to characterize albuterol-induced DNAm changes in airway epithelial cells, and assess potential functional consequences and the influence of genetic variation and asthma-related clinical variables.

resultsWe followed a discovery and validation study design to characterize albuterol-induced DNAm changes in paired airway epithelial cultures stimulated in vitro with albuterol. In the discovery phase, an epigenome-wide association study using paired nasal epithelial cultures from Puerto Rican children (n = 97) identified 22 CpGs genome-wide associated with repeated-use albuterol treatment (p < 9 × 10

conclusionsThis study revealed evidence of epigenetic modifications induced by albuterol in the mucociliary airway epithelium. The epigenomic response induced by albuterol might have potential clinical implications by affecting biological pathways relevant to asthma.

Indexed as

AsthmaDNA MethylationAlbuterolBronchodilator AgentsChildEpigenesis, GeneticEpigenomicsEpithelial CellsGenome-Wide Association StudyHumansAlbuterolBronchodilator AgentsAirway cellsAlbuterolCREB3L1DNA methylationEpigeneticsEWASKSR1MYLK4Puerto Ricansβ2-agonist

Identifiers

PMID37784136
PMCPMC10546710
OpenAlexW4387296095

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.