Evidence map›Paper›PMID 37787964›Full record

ArticleCardiovascular toxicology2023

Systematical Evaluation of the Structure-Cardiotoxicity Relationship of 7-Azaindazole-based PI3K Inhibitors Designed by Bioisosteric Approach.

Tianze Wu, Yi Chen, Chengbin Yang, Mingzhu Lu, Fang Geng, Jianhua Guo, Yan Pi, Yun Ling, Jun Xu, Tong Cai and 2 more

Abstract read
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In one paragraph

Article in Cardiovascular toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Quercetin is a foe in the heart by targeting the hERG potassium channel.Iranian journal of basic medical sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Tianze WuDepartment of Chemistry, Fudan University, Shanghai, 200433, China.
Yi ChenDepartment of Chemistry, Fudan University, Shanghai, 200433, China.
Chengbin YangDepartment of Chemistry, Fudan University, Shanghai, 200433, China.
Mingzhu LuDepartment of Chemistry, Fudan University, Shanghai, 200433, China.
Fang GengSchool of Life Sciences, Fudan University, Shanghai, 200438, China.
Jianhua GuoSchool of Life Sciences, Fudan University, Shanghai, 200438, China.
Yan PiSchool of Life Sciences, Fudan University, Shanghai, 200438, China.
Yun LingDepartment of Chemistry, Fudan University, Shanghai, 200433, China.
Jun XuABA Chemicals Co., Ltd, Taicang, 215400, Jiangsu, China.
Tong CaiABA Chemicals Co., Ltd, Taicang, 215400, Jiangsu, China.
Lei LuSchool of Life Sciences, Fudan University, Shanghai, 200438, China.
Yaming ZhouDepartment of Chemistry, Fudan University, Shanghai, 200433, China. ymzhou@fudan.edu.cn.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A growing concern of cardiotoxicity induced by PI3K inhibitors has raised the requirements to evaluate the structure-cardiotoxicity relationship (SCR) in the development process of novel inhibitors. Based on three bioisosteric 7-azaindazole-based candidate inhibitors namely FD269, FD268 and FD274 that give same order of inhibitory concentration 50% (IC

Indexed as

CardiotoxicityZebrafishAnimalsEmbryo, NonmammalianHeartPhosphatidylinositol 3-KinasesPhosphatidylinositol 3-KinasesBioisosteric replacementNoxo1bOxidative stressStructure-cardiotoxicity relationshipZebrafish

Identifiers

PMID37787964
OpenAlexW4387296714

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.