Evidence map›Paper›PMID 37788332›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2023

Stabilization of

Shelley R Wang, Caroline G Mallard, Cassandra A Cairns, Hee Kyoung Chung, Dongyoon Yoo, Suraj K Jaladanki, Lan Xiao, Jian-Ying Wang

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Polyamines regulate mitochondrial metabolism essential for intestinal epithelial renewal and wound healing.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shelley R WangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Caroline G MallardCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Cassandra A CairnsCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-4364-4418
Hee Kyoung ChungCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Dongyoon YooCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Suraj K JaladankiCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Lan XiaoCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Jian-Ying WangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0003-3002-1040
University of Maryland, Baltimore · US

Funding

Intestinal Mucosal Growth in Health & Surgical DiseasesR01DK057819 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Jian-Ying Wang · 2000 to 2026
$7.4M
Surgical Studies of Gut PermeabilityR01DK068491 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Jian-Ying Wang · 2004 to 2026
$7.0M
Mucosal Repair in Gut Surgical DisordersR01DK061972 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WANG, JIAN-YING · 2002 to 2023
$6.7M
NIDDK NIH HHS R01 DK057819NIDDK NIH HHS R01 DK061972NIDDK NIH HHS R01 DK068491
6 · The paper itself

Abstract

Gut barrier dysfunction occurs commonly in patients with critical disorders, leading to the translocation of luminal toxic substances and bacteria to the bloodstream. Connexin 43 (Cx43) acts as a gap junction protein and is crucial for intercellular communication and the diffusion of nutrients. The levels of cellular Cx43 are tightly regulated by multiple factors, including polyamines, but the exact mechanism underlying the control of Cx43 expression remains largely unknown. The RNA-binding protein HuR regulates the stability and translation of target mRNAs and is involved in many aspects of intestinal epithelial pathobiology. Here we show that HuR directly bound to

Indexed as

Connexin 43ELAV-Like Protein 1PolyaminesRNA, MessengerHumansIntestinal MucosaRNA StabilityConnexin 43ELAV-Like Protein 1PolyaminesRNA, Messengergut barrier functionintestinal epithelial cellsmRNA stabilitypolyaminesRNA-binding proteins

Identifiers

PMID37788332
PMCPMC10894663
OpenAlexW4387303251

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.