Evidence map›Paper›PMID 37788485›Full record

ReviewJournal of radiation research2023

Radiation-induced gastric injury during radiotherapy: molecular mechanisms and clinical treatment.

Guangxia Chen, Zuxiang Yu, Yuehua Zhang, Shiyu Liu, Chong Chen, Shuyu Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Journal of radiation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. The role of p38 MAPK in acteoside-mediated gastric ulcer protection.International journal of medical sciences · 2026
    Article
  3. Review
  4. Review
  5. Histotripsy of the hepatic capsule and the gastric wall: acute treatment effects in a swine model.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Guangxia ChenDepartment of Gastroenterology, The First People's Hospital of Xuzhou, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou 221200, China.
Zuxiang YuLaboratory of Radiation Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Yuehua ZhangLaboratory of Radiation Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Shiyu LiuDepartment of Gastroenterology, The First People's Hospital of Xuzhou, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou 221200, China.
Chong ChenDepartment of Gastroenterology, The First People's Hospital of Xuzhou, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou 221200, China.
Shuyu ZhangLaboratory of Radiation Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
West China Medical Center of Sichuan University · CNXuzhou No.1 People's Hospital · CNChina National Nuclear Corporation · CNXuzhou Medical College · CN

Funding

National Natural Science Foundation of China 82073477Scientific Fund for Distinguished Young Scholars in Sichuan Province 2022JDJQ0051Xuzhou Health and Health Commission Youth Innovation Science and Technology Project XWKYHT20220073Xuzhou Key Research & Development Program Project KC22111
6 · The paper itself

Abstract

Radiotherapy (RT) has been the standard of care for treating a multitude of cancer types. Radiation-induced gastric injury (RIGI) is a common complication of RT for thoracic and abdominal tumors. It manifests acutely as radiation gastritis or gastric ulcers, and chronically as chronic atrophic gastritis or intestinal metaplasia. In recent years, studies have shown that intracellular signals such as oxidative stress response, p38/MAPK pathway and transforming growth factor-β signaling pathway are involved in the progression of RIGI. This review also summarized the risk factors, diagnosis and treatment of this disease. However, the root of therapeutic challenges lies in the incomplete understanding of the mechanisms. Here, we also highlight the potential mechanistic, diagnostic and therapeutic directions of RIGI.

Indexed as

Gastritis, AtrophicStomach NeoplasmsStomach UlcerHumansOxidative StressRisk Factorsdiagnosisionizing radiationradiation-induced gastric injury (RIGI)radiotherapy (RT)treatment

Identifiers

PMID37788485
PMCPMC10665304
OpenAlexW4387298584

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.