ArticleBMC genomic data2023
Genome-wide identification, comparative analysis and functional roles in flavonoid biosynthesis of cytochrome P450 superfamily in pear (Pyrus spp.).
Article in BMC genomic data, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 28 citations in OpenAlex.
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- Comparative genomics and evolutionary insights in divergence and expression of CYP450 super gene family in citrus (C. sinensis, C. grandis&P. trifoliata).BMC plant biology · 2025Article
- Proposed EU NGT legislation in light of plant genetic variation.Plant biotechnology journal · 2025Review
- Comprehensive analysis and expression characterization of potato Cytochrome P450 gene family and the role of StCYP67 in abiotic stresses.BMC plant biology · 2025Article
- Time-Series Metabolome and Transcriptome Analyses Reveal the Genetic Basis of Vanillin Biosynthesis in Vanilla.Plants (Basel, Switzerland) · 2025Article
- Genome-wide identification and expression analyses of CYP450 genes in Chrysanthemum indicum.BMC genomics · 2025Article
- Genome-Wide Identification and Transcriptome Analysis of P450 Superfamily Genes in Flax (International journal of molecular sciences · 2025Article
- GHCYP706A7 governs anthocyanin biosynthesis to mitigate ROS under alkali stress in cotton.Plant cell reports · 2025Article
- Genome-wide screen and multi-omics analysis revealHorticulture research · 2024Article
- Genome-wide identification and functional analysis of CYP450 genes in eggplant (Solanum melongena L.) with a focus on anthocyanin accumlation.BMC genomics · 2024Article
- Genome-Wide Identification and Characterization of Diterpenoid Pathway CYPs inInternational journal of molecular sciences · 2024Article
- Genome-wide identification and expression analyses of CYP450 genes in sweet potato (Ipomoea batatas L.).BMC genomics · 2024Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cytochrome P450 (CYP) superfamily is the largest enzyme metabolism family in plants identified to date, and it is involved in many biological processes, including secondary metabolite biosynthesis, hormone metabolism and stress resistance. However, the P450 gene superfamily has not been well studied in pear (Pyrus spp.).
resultsHere, the comprehensive identification and a comparative analysis of P450 superfamily members were conducted in cultivated and wild pear genomes. In total, 338, 299 and 419 P450 genes were identified in Chinese white pear, European pear and the wild pear, respectively. Based on the phylogenetic analyses, pear P450 genes were divided into ten clans, comprising 48 families. The motif and gene structure analyses further supported this classification. The expansion of the pear P450 gene family was attributed to whole-genome and single-gene duplication events. Several P450 gene clusters were detected, which have resulted from tandem and proximal duplications. Purifying selection was the major force imposed on the long-term evolution of P450 genes. Gene dosage balance, subfunctionalization and neofunctionalization jointly drove the retention and functional diversification of P450 gene pairs. Based on the association analysis between transcriptome expression profiles and flavonoid content during fruit development, three candidate genes were identified as being closely associated with the flavonoid biosynthesis, and the expression of one gene was further verified using qRT-PCR and its function was validated through transient transformation in pear fruit.
conclusionsThe study results provide insights into the evolution and biological functions of P450 genes in pear.
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